Association of Alzheimer's disease polygenic risk score with concussion severity and recovery metrics

Kaitlyn Marie Dybing, Thomas W. McAllister, Yu-Chien Wu, Brenna C. McDonald, Steven P. Broglio, Jason P. Mihalik, Kevin M. Guskiewicz, Joshua T. Goldman, Jonathan C. Jackson, Shannon L. Risacher, Andrew J. Saykin, Kelly N. H. Nudelman
{"title":"Association of Alzheimer's disease polygenic risk score with concussion severity and recovery metrics","authors":"Kaitlyn Marie Dybing, Thomas W. McAllister, Yu-Chien Wu, Brenna C. McDonald, Steven P. Broglio, Jason P. Mihalik, Kevin M. Guskiewicz, Joshua T. Goldman, Jonathan C. Jackson, Shannon L. Risacher, Andrew J. Saykin, Kelly N. H. Nudelman","doi":"10.1101/2024.07.10.24309042","DOIUrl":null,"url":null,"abstract":"Identification of genetic alleles associated with both Alzheimer's disease (AD) and concussion severity/recovery could help explain\nthe association between concussion and elevated dementia risk. However, there has been little investigation into whether AD risk\ngenes associate with concussion severity/recovery, and the limited findings are mixed. We used AD polygenic risk scores (PRS) and\nAPOE genotypes to investigate any such associations in the NCAA-DoD Grand Alliance CARE Consortium (CARE) dataset. We\nassessed six outcomes in 931 total participants. The outcomes were two concussion recovery measures (number of days to\nasymptomatic status, number of days to return to play (RTP)) and four concussion severity measures (scores on SAC and BESS,\nSCAT symptom severity, and total number of symptoms). We calculated PRS using a published score [1] and performed multiple\nlinear regression (MLR) to assess the relationship of PRS with the outcomes. We also used t-tests and chi-square tests to examine\noutcomes by APOE genotype, and MLR to analyze outcomes in European and African genetic ancestry subgroups. Higher PRS was\nassociated with longer injury to RTP in the normal RTP (<24 days) subgroup (p = 0.024), and one standard deviation increase in PRS\nresulted in a 9.89 hour increase to the RTP interval. There were no other consistently significant effects, suggesting that high AD\ngenetic risk is not strongly associated with more severe concussions or poor recovery in young adults. Future studies should attempt to\nreplicate these findings in larger samples with longer follow-up using PRS calculated from diverse populations.","PeriodicalId":501122,"journal":{"name":"medRxiv - Sports Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Sports Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.07.10.24309042","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Identification of genetic alleles associated with both Alzheimer's disease (AD) and concussion severity/recovery could help explain the association between concussion and elevated dementia risk. However, there has been little investigation into whether AD risk genes associate with concussion severity/recovery, and the limited findings are mixed. We used AD polygenic risk scores (PRS) and APOE genotypes to investigate any such associations in the NCAA-DoD Grand Alliance CARE Consortium (CARE) dataset. We assessed six outcomes in 931 total participants. The outcomes were two concussion recovery measures (number of days to asymptomatic status, number of days to return to play (RTP)) and four concussion severity measures (scores on SAC and BESS, SCAT symptom severity, and total number of symptoms). We calculated PRS using a published score [1] and performed multiple linear regression (MLR) to assess the relationship of PRS with the outcomes. We also used t-tests and chi-square tests to examine outcomes by APOE genotype, and MLR to analyze outcomes in European and African genetic ancestry subgroups. Higher PRS was associated with longer injury to RTP in the normal RTP (<24 days) subgroup (p = 0.024), and one standard deviation increase in PRS resulted in a 9.89 hour increase to the RTP interval. There were no other consistently significant effects, suggesting that high AD genetic risk is not strongly associated with more severe concussions or poor recovery in young adults. Future studies should attempt to replicate these findings in larger samples with longer follow-up using PRS calculated from diverse populations.
阿尔茨海默病多基因风险评分与脑震荡严重程度和恢复指标的关系
确定与阿尔茨海默病(AD)和脑震荡严重程度/恢复有关的遗传等位基因有助于解释脑震荡与痴呆症风险升高之间的关联。然而,关于阿兹海默症风险基因是否与脑震荡严重程度/恢复相关的研究却很少,有限的研究结果也是喜忧参半。我们使用 AD 多基因风险评分 (PRS) 和APOE 基因型来调查 NCAA-DoD 大联盟 CARE 联合会 (CARE) 数据集中的任何此类关联。我们对 931 名参与者的六项结果进行了评估。这些结果包括两项脑震荡恢复指标(达到无症状状态的天数、恢复比赛(RTP)的天数)和四项脑震荡严重程度指标(SAC 和 BESS 评分、SCAT 症状严重程度和症状总数)。我们使用已公布的评分[1]计算PRS,并进行多元线性回归(MLR)以评估PRS与结果之间的关系。我们还使用 t 检验和卡方检验来检查 APOE 基因型的结果,并使用 MLR 分析欧洲和非洲基因血统亚组的结果。在正常 RTP(24 天)亚组中,较高的 PRS 与较长的 RTP 损伤相关(p = 0.024),PRS 增加一个标准差导致 RTP 间隔增加 9.89 小时。没有其他持续显著的影响,这表明高AD遗传风险与青壮年更严重的脑震荡或恢复不良并无密切关系。未来的研究应尝试使用从不同人群中计算出的 PRS,在更大样本和更长时间的随访中重复这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信