Association of diabetes mellitus with risk of reproductive impairment in females: A comprehensive review

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-07-14 DOI:10.1016/j.acthis.2024.152173

Nida Andlib, Mohd Sajad, Sonu Chand Thakur

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Abstract

Reproductive impairment is the most prevalent yet most ignored complication of diabetes mellitus. In diabetes, the problem associated with reproductive health is comprehensive in both males and females. Diabetic females have problems like delayed menarche, irregular menstrual cycle, subfertility, complications in pregnancy and early menopause. This may decrease reproductive age in diabetic females as the menarche is delayed and menopause is early in them. Like diabetic males, diabetic females also have the negative effect of oxidative stress on the reproductive system. This may lead to dysfunction of the ovary. It affects the physiological cycle like the ovary’s maturation, embryo development and pregnancy. These complications also affect the offspring, and they may also become diabetic. This review aims to concentrate on the effect of diabetes on the reproductive system of females and the impairment caused by it. We will also discuss in detail the role of the hypothalamus-pituitary ovary axis, diabetes impact on different reproductive phases of females, and the sexual disorders that occur in them.

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糖尿病与女性生殖障碍风险的关系：综述

生殖功能损害是糖尿病最常见但最容易被忽视的并发症。在糖尿病患者中，与生殖健康相关的问题在男性和女性中都很普遍。女性糖尿病患者会出现月经初潮推迟、月经周期不规律、不孕、妊娠并发症和更年期提前等问题。这可能会降低糖尿病女性的生育年龄，因为她们的初潮推迟，更年期提前。与男性糖尿病患者一样，女性糖尿病患者的生殖系统也会受到氧化应激的负面影响。这可能会导致卵巢功能失调。它会影响卵巢成熟、胚胎发育和怀孕等生理周期。这些并发症也会影响后代，他们也可能成为糖尿病患者。本综述旨在集中探讨糖尿病对女性生殖系统的影响及其造成的损害。我们还将详细讨论下丘脑-垂体-卵巢轴的作用、糖尿病对女性不同生殖阶段的影响以及女性出现的性功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464