Oscar Jalnefjord, Louise Rosenqvist, Amina Warsame, Isabella M Björkman-Burtscher
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引用次数: 0
Abstract
Objectives: Signal drift has been put forward as one of the fundamental confounding factors in diffusion MRI (dMRI) of the brain. This study characterizes signal drift in dMRI of the brain, evaluates correction methods, and exemplifies its impact on parameter estimation for three intravoxel incoherent motion (IVIM) protocols.
Materials and methods: dMRI of the brain was acquired in ten healthy subjects using protocols designed to enable retrospective characterization and correction of signal drift. All scans were acquired twice for repeatability analysis. Three temporal polynomial correction methods were evaluated: (1) global, (2) voxelwise, and (3) spatiotemporal. Effects of acquisition order were simulated using estimated drift fields.
Results: Signal drift was around 2% per 5 min in the brain as a whole, but reached above 5% per 5 min in the frontal regions. Only correction methods taking spatially varying signal drift into account could achieve effective corrections. Altered acquisition order introduced both systematic changes and differences in repeatability in the presence of signal drift.
Discussion: Signal drift in dMRI of the brain was found to be spatially varying, calling for correction methods taking this into account. Without proper corrections, choice of protocol can affect dMRI parameter estimates and their repeatability.
期刊介绍:
MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include:
advances in materials, hardware and software in magnetic resonance technology,
new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine,
study of animal models and intact cells using magnetic resonance,
reports of clinical trials on humans and clinical validation of magnetic resonance protocols.