The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo.

IF 3.3 3区 生物学 Q2 GENETICS & HEREDITY
Genetics Pub Date : 2024-08-07 DOI:10.1093/genetics/iyae072
Meera V Sundaram, Nathalie Pujol
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引用次数: 0

Abstract

Apical extracellular matrices (aECMs) coat the exposed surfaces of animal bodies to shape tissues, influence social interactions, and protect against pathogens and other environmental challenges. In the nematode Caenorhabditis elegans, collagenous cuticle and zona pellucida protein-rich precuticle aECMs alternately coat external epithelia across the molt cycle and play many important roles in the worm's development, behavior, and physiology. Both these types of aECMs contain many matrix proteins related to those in vertebrates, as well as some that are nematode-specific. Extensive differences observed among tissues and life stages demonstrate that aECMs are a major feature of epithelial cell identity. In addition to forming discrete layers, some cuticle components assemble into complex substructures such as ridges, furrows, and nanoscale pillars. The epidermis and cuticle are mechanically linked, allowing the epidermis to sense cuticle damage and induce protective innate immune and stress responses. The C. elegans model, with its optical transparency, facilitates the study of aECM cell biology and structure/function relationships and all the myriad ways by which aECM can influence an organism.

秀丽隐杆线虫的角质层和前角质层:研究体内动态顶端细胞外基质的模型。
顶端胞外基质(aECMs)包裹着动物身体的暴露表面,从而塑造组织、影响社会互动、抵御病原体和其他环境挑战。在线虫秀丽隐杆线虫(Caenorhabditis elegans)中,胶原角质层和富含透明带蛋白的前表皮细胞外基质(precuticle aECMs)在整个蜕皮周期中交替包裹外部上皮,在蠕虫的发育、行为和生理过程中发挥着许多重要作用。这两种前表皮细胞膜都含有许多与脊椎动物相关的基质蛋白,以及一些线虫特有的基质蛋白。在不同组织和生命阶段观察到的广泛差异表明,aECMs 是上皮细胞特性的一个主要特征。除了形成离散层外,一些角质层成分还组合成复杂的亚结构,如脊、沟和纳米级支柱。表皮和角质层是机械连接的,这使得表皮能够感知角质层的损伤,并诱导保护性的先天免疫和应激反应。眼镜蛇模型具有光学透明性,有助于研究表皮细胞生物学、结构/功能关系以及表皮细胞影响生物体的各种方式。
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来源期刊
Genetics
Genetics GENETICS & HEREDITY-
CiteScore
6.90
自引率
6.10%
发文量
177
审稿时长
1.5 months
期刊介绍: GENETICS is published by the Genetics Society of America, a scholarly society that seeks to deepen our understanding of the living world by advancing our understanding of genetics. Since 1916, GENETICS has published high-quality, original research presenting novel findings bearing on genetics and genomics. The journal publishes empirical studies of organisms ranging from microbes to humans, as well as theoretical work. While it has an illustrious history, GENETICS has changed along with the communities it serves: it is not your mentor''s journal. The editors make decisions quickly – in around 30 days – without sacrificing the excellence and scholarship for which the journal has long been known. GENETICS is a peer reviewed, peer-edited journal, with an international reach and increasing visibility and impact. All editorial decisions are made through collaboration of at least two editors who are practicing scientists. GENETICS is constantly innovating: expanded types of content include Reviews, Commentary (current issues of interest to geneticists), Perspectives (historical), Primers (to introduce primary literature into the classroom), Toolbox Reviews, plus YeastBook, FlyBook, and WormBook (coming spring 2016). For particularly time-sensitive results, we publish Communications. As part of our mission to serve our communities, we''ve published thematic collections, including Genomic Selection, Multiparental Populations, Mouse Collaborative Cross, and the Genetics of Sex.
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