Impacts of pleiotropy and migration on repeated genetic adaptation.

IF 3.3 3区 生物学 Q2 GENETICS & HEREDITY
Genetics Pub Date : 2024-09-04 DOI:10.1093/genetics/iyae111
Paul Battlay, Sam Yeaman, Kathryn A Hodgins
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引用次数: 0

Abstract

Observations of genetically repeated evolution (repeatability) in complex organisms are incongruent with the Fisher-Orr model, which implies that repeated use of the same gene should be rare when mutations are pleiotropic (i.e. affect multiple traits). When spatially divergent selection occurs in the presence of migration, mutations of large effect are more strongly favored, and hence, repeatability is more likely, but it is unclear whether this observation is limited by pleiotropy. Here, we explore this question using individual-based simulations of a two-patch model incorporating multiple quantitative traits governed by mutations with pleiotropic effects. We explore the relationship between fitness trade-offs and repeatability by varying the alignment between mutation effect and spatial variation in trait optima. While repeatability decreases with increasing trait dimensionality, trade-offs in mutation effects on traits do not strongly limit the contribution of a locus of large effect to repeated adaptation, particularly under increased migration. These results suggest that repeatability will be more pronounced for local rather than global adaptation. Whereas pleiotropy limits repeatability in a single-population model, when there is local adaptation with gene flow, repeatability can occur if some loci are able to produce alleles of large effect, even when there are pleiotropic trade-offs.

多效性和迁移对重复遗传适应的影响。
在复杂生物体中观察到的基因重复进化(可重复性)与费雪-奥尔模型(Fisher-Orr model)不一致,费雪-奥尔模型暗示,当突变具有多效性(即影响多个性状)时,重复使用同一基因的情况应该很少见。当迁移过程中出现空间差异选择时,影响大的突变更受青睐,因此重复使用的可能性更大,但目前还不清楚这一观察结果是否受多向性的限制。在这里,我们利用基于个体的模拟来探讨这个问题,模拟的双配位模型包含了由具有多向效应的突变所控制的多个数量性状。我们通过改变突变效应与性状最佳值的空间变化之间的一致性来探索适应性权衡与可重复性之间的关系。虽然可重复性会随着性状维度的增加而降低,但性状突变效应的权衡并不会强烈限制大效应位点对重复适应的贡献,尤其是在迁移增加的情况下。这些结果表明,重复适应性在局部而非全局适应中更为明显。在单种群模型中,多效性限制了可重复性,而当存在基因流动的局部适应时,如果某些位点能够产生大效应等位基因,即使存在多效性权衡,也会出现可重复性。
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来源期刊
Genetics
Genetics GENETICS & HEREDITY-
CiteScore
6.90
自引率
6.10%
发文量
177
审稿时长
1.5 months
期刊介绍: GENETICS is published by the Genetics Society of America, a scholarly society that seeks to deepen our understanding of the living world by advancing our understanding of genetics. Since 1916, GENETICS has published high-quality, original research presenting novel findings bearing on genetics and genomics. The journal publishes empirical studies of organisms ranging from microbes to humans, as well as theoretical work. While it has an illustrious history, GENETICS has changed along with the communities it serves: it is not your mentor''s journal. The editors make decisions quickly – in around 30 days – without sacrificing the excellence and scholarship for which the journal has long been known. GENETICS is a peer reviewed, peer-edited journal, with an international reach and increasing visibility and impact. All editorial decisions are made through collaboration of at least two editors who are practicing scientists. GENETICS is constantly innovating: expanded types of content include Reviews, Commentary (current issues of interest to geneticists), Perspectives (historical), Primers (to introduce primary literature into the classroom), Toolbox Reviews, plus YeastBook, FlyBook, and WormBook (coming spring 2016). For particularly time-sensitive results, we publish Communications. As part of our mission to serve our communities, we''ve published thematic collections, including Genomic Selection, Multiparental Populations, Mouse Collaborative Cross, and the Genetics of Sex.
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