Advances in the management of parathyroid carcinoma

IF 3.8 3区医学 Q2 CELL BIOLOGY

Molecular and Cellular Endocrinology Pub Date : 2024-07-11 DOI:10.1016/j.mce.2024.112329

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Abstract

Parathyroid carcinoma (PCA) is a rare malignancy accounting for approximately 1% of all patients with primary hyperparathyroidism. It is characterised by excessive parathyroid hormone (PTH) production. This manuscript reviews recent advances in the management of parathyroid carcinoma, focusing on molecular insights, diagnostic modalities, surgical innovations, adjuvant therapies, and emerging targeted treatments. Recently published manuscripts (between 2022 and 2023) were obtained from Medical Literature Analysis and Retrieval System Online (Medline), Excerpta Medica (Embase), Cochrane Central Register of Controlled Trials (CENTRAL), and European Union Drug Regulating Authorities Clinical Trials (EudraCT). These were assessed for their relevance in terms of the diagnosis and management of patients with PCA. This manuscript explores the role of genetic profiling and presents case studies illustrating successful management strategies. The manuscript also discusses the ongoing challenges in the management of parathyroid carcinoma, suggesting future research directions and potential therapeutic avenues.

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甲状旁腺癌的治疗进展。

甲状旁腺癌（PCA）是一种罕见的恶性肿瘤，约占所有原发性甲状旁腺功能亢进症患者的1%。其特点是甲状旁腺激素（PTH）分泌过多。本手稿回顾了甲状旁腺癌治疗的最新进展，重点关注分子见解、诊断方式、手术创新、辅助疗法和新兴靶向治疗。我们从医学文献分析与检索系统在线版（Medline）、Excerpta Medica（Embase）、Cochrane对照试验中央注册中心（CENTRAL）和欧盟药物管理局临床试验（EudraCT）中获取了近期发表的手稿（2022年至2023年）。我们评估了这些研究与 PCA 患者诊断和管理的相关性。本手稿探讨了基因图谱分析的作用，并通过案例研究说明了成功的管理策略。手稿还讨论了甲状旁腺癌治疗过程中面临的挑战，提出了未来的研究方向和潜在的治疗途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular and Cellular Endocrinology 医学-内分泌学与代谢

CiteScore

9.00

自引率

2.40%

发文量

174

审稿时长

42 days

期刊介绍： Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.

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