Venous Thromboembolism Following COVID-19 Vaccination in Patients With Hereditary Protein S Deficiency.

IF 1.3 Q4 HEMATOLOGY
Journal of hematology Pub Date : 2024-06-01 Epub Date: 2024-06-28 DOI:10.14740/jh1278
Molly Rayner, Kelsey Brose
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引用次数: 0

Abstract

Hereditary protein S (PS) deficiency is a rare condition associated with increased risk of venous thromboembolism (VTE). In 2020, the coronavirus disease 2019 (COVID-19) pandemic prompted development of vaccinations to protect against the virus. PS deficiency is not a contraindication to COVID-19 vaccinations, but there are no studies regarding potential adverse effects in this population. We report two cases, a 43-year-old mother and her 18-year-old son, who developed VTE shortly after their first COVID-19 vaccines. Testing confirmed hereditary PS deficiency with a previously undescribed mutation in both cases. The temporal association between COVID-19 vaccination and VTE in these patients with hereditary PS deficiency suggests a potential causal relationship. However, it is unclear if this applies to all patients with hereditary PS deficiency. This highlights the importance of reporting adverse events following COVID-19 vaccinations in this population to evaluate the risks and benefits of vaccination.

遗传性蛋白 S 缺乏症患者接种 COVID-19 疫苗后出现静脉血栓栓塞。
遗传性蛋白 S(PS)缺乏症是一种罕见疾病,与静脉血栓栓塞症(VTE)风险增加有关。2020 年,冠状病毒病 2019(COVID-19)大流行促使人们开发疫苗来预防该病毒。PS 缺乏症并不是接种 COVID-19 疫苗的禁忌症,但目前还没有关于该人群潜在不良反应的研究。我们报告了两个病例,一位是 43 岁的母亲,另一位是她 18 岁的儿子,他们在首次接种 COVID-19 疫苗后不久出现了 VTE。检测证实,这两个病例都患有遗传性 PS 缺乏症,且存在以前未曾描述过的突变。这些遗传性 PS 缺乏症患者接种 COVID-19 疫苗与 VTE 之间的时间关联表明两者之间可能存在因果关系。但目前还不清楚这是否适用于所有遗传性 PS 缺乏症患者。这凸显了报告该人群接种 COVID-19 疫苗后发生不良事件的重要性,以评估接种疫苗的风险和益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of hematology
Journal of hematology HEMATOLOGY-
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发文量
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