The bidirectional interaction between antidepressants and the gut microbiota: are there implications for treatment response?

IF 2.1 3区 医学 Q3 PHARMACOLOGY & PHARMACY
Gianluca Borgiani, Chiara Possidente, Chiara Fabbri, Vincenzo Oliva, Mirjam Bloemendaal, Alejandro Arias Vasquez, Ted G Dinan, Eduard Vieta, Marco Menchetti, Diana De Ronchi, Alessandro Serretti, Giuseppe Fanelli
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引用次数: 0

Abstract

This review synthesizes the evidence on associations between antidepressant use and gut microbiota composition and function, exploring the microbiota's possible role in modulating antidepressant treatment outcomes. Antidepressants exert an influence on measures of gut microbial diversity. The most consistently reported differences were in β-diversity between those exposed to antidepressants and those not exposed, with longitudinal studies supporting a potential causal association. Compositional alterations in antidepressant users include an increase in the Bacteroidetes phylum, Christensenellaceae family, and Bacteroides and Clostridium genera, while a decrease was found in the Firmicutes phylum, Ruminococcaceae family, and Ruminococcus genus. In addition, antidepressants attenuate gut microbial differences between depressed and healthy individuals, modulate microbial serotonin transport, and influence microbiota's metabolic functions. These include lyxose degradation, peptidoglycan maturation, membrane transport, and methylerythritol phosphate pathways, alongside gamma-aminobutyric acid metabolism. Importantly, baseline increased α-diversity and abundance of the Roseburia and Faecalibacterium genera, in the Firmicutes phylum, are associated with antidepressant response, emerging as promising biomarkers. This review highlights the potential for gut microbiota as a predictor of treatment response and emphasizes the need for further research to elucidate the mechanisms underlying antidepressant-microbiota interactions. More homogeneous studies and standardized techniques are required to confirm these initial findings.

抗抑郁药与肠道微生物群之间的双向作用:对治疗反应有影响吗?
本综述综合了抗抑郁药物的使用与肠道微生物群的组成和功能之间相关性的证据,探讨了微生物群在调节抗抑郁治疗效果方面可能发挥的作用。抗抑郁药对肠道微生物多样性的测量产生了影响。最常报道的差异是暴露于抗抑郁药和未暴露于抗抑郁药者之间的β多样性差异,纵向研究支持这种潜在的因果关系。抗抑郁药使用者体内的组成变化包括:类杆菌门、克里斯坦森菌科、类杆菌属和梭状芽孢杆菌属的数量增加,而真菌门、反刍球菌科和反刍球菌属的数量减少。此外,抗抑郁药还能减弱抑郁症患者与健康人之间的肠道微生物差异,调节微生物的血清素转运,并影响微生物群的代谢功能。这些功能包括裂糖降解、肽聚糖成熟、膜转运、赤藓糖醇磷酸酯途径以及γ-氨基丁酸代谢。重要的是,基线增加的α多样性和丰度与抗抑郁药反应有关,是有前途的生物标志物。本综述强调了肠道微生物群作为治疗反应预测因子的潜力,并强调了进一步研究以阐明抗抑郁药物与微生物群相互作用机制的必要性。要证实这些初步发现,还需要更多的同质研究和标准化技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
23.10%
发文量
97
审稿时长
>12 weeks
期刊介绍: International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes. A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.
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