Association between primary biliary cholangitis with diabetes and cardiovascular diseases: A bidirectional multivariable Mendelian randomization study

IF 2.6 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinics and research in hepatology and gastroenterology Pub Date : 2024-07-09 DOI:10.1016/j.clinre.2024.102419

{"title":"Association between primary biliary cholangitis with diabetes and cardiovascular diseases: A bidirectional multivariable Mendelian randomization study","authors":"","doi":"10.1016/j.clinre.2024.102419","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and aims</h3><p>Primary biliary cholangitis (PBC) is an autoimmune disease often accompanied by multisystem damage. This study aimed to explore the causal association between genetically predicted PBC and diabetes, as well as multiple cardiovascular diseases (CVDs).</p></div><div><h3>Methods</h3><p>Genome-wide association studies (GWAS) summary data of PBC in 24,510 individuals of European ancestry from the European Association for the Study of the Liver was used to identify genetically predicted PBC. We conducted 2-sample single-variable Mendelian randomization (SVMR) and multivariable Mendelian randomization (MVMR) to estimate the impacts of PBC on diabetes (<em>N</em> = 17,685 to 318,014) and 20 CVDs from the genetic consortium (<em>N</em> = 171,875 to 1,030,836).</p></div><div><h3>Results</h3><p>SVMR provided evidence that genetically predicted PBC is associated with an increased risk of type 1 diabetes (T1D), type 2 diabetes (T2D), myocardial infarction (MI), heart failure (HF), hypertension, atrial fibrillation (AF), stroke, ischemic stroke, and small-vessel ischemic stroke. Additionally, there was no evidence of a causal association between PBC and coronary atherosclerosis. In the MVMR analysis, PBC maintained independent effects on T1D, HF, MI, and small-vessel ischemic stroke in most models.</p></div><div><h3>Conclusion</h3><p>Our findings revealed the causal effects of PBC on diabetes and 7 CVDs, and no causal relationship was detected between PBC and coronary atherosclerosis.</p></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"48 7","pages":"Article 102419"},"PeriodicalIF":2.6000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinics and research in hepatology and gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210740124001402","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background and aims

Primary biliary cholangitis (PBC) is an autoimmune disease often accompanied by multisystem damage. This study aimed to explore the causal association between genetically predicted PBC and diabetes, as well as multiple cardiovascular diseases (CVDs).

Methods

Genome-wide association studies (GWAS) summary data of PBC in 24,510 individuals of European ancestry from the European Association for the Study of the Liver was used to identify genetically predicted PBC. We conducted 2-sample single-variable Mendelian randomization (SVMR) and multivariable Mendelian randomization (MVMR) to estimate the impacts of PBC on diabetes (N = 17,685 to 318,014) and 20 CVDs from the genetic consortium (N = 171,875 to 1,030,836).

Results

SVMR provided evidence that genetically predicted PBC is associated with an increased risk of type 1 diabetes (T1D), type 2 diabetes (T2D), myocardial infarction (MI), heart failure (HF), hypertension, atrial fibrillation (AF), stroke, ischemic stroke, and small-vessel ischemic stroke. Additionally, there was no evidence of a causal association between PBC and coronary atherosclerosis. In the MVMR analysis, PBC maintained independent effects on T1D, HF, MI, and small-vessel ischemic stroke in most models.

Conclusion

Our findings revealed the causal effects of PBC on diabetes and 7 CVDs, and no causal relationship was detected between PBC and coronary atherosclerosis.

查看原文本刊更多论文

原发性胆汁性胆管炎与糖尿病和心血管疾病的关系：一项双向多变量孟德尔随机研究。

背景和目的：原发性胆汁性胆管炎（PBC）是一种自身免疫性疾病，通常伴有多系统损害。本研究旨在探讨基因预测的 PBC 与糖尿病以及多种心血管疾病（CVDs）之间的因果关系：方法：我们使用欧洲肝脏研究协会提供的 24,510 名欧洲血统 PBC 患者的全基因组关联研究（GWAS）汇总数据来识别遗传预测的 PBC。我们进行了双样本单变量孟德尔随机化（SVMR）和多变量孟德尔随机化（MVMR），以估计 PBC 对糖尿病（N = 17,685 至 318,014 例）和遗传联盟中 20 种心血管疾病（N = 171,875 至 1,030,836 例）的影响：SVMR 提供的证据表明，遗传预测的 PBC 与 1 型糖尿病 (T1D)、2 型糖尿病 (T2D)、心肌梗死 (MI)、心力衰竭 (HF)、高血压、心房颤动 (AF)、中风、缺血性中风和小血管缺血性中风的风险增加有关。此外，没有证据表明 PBC 与冠状动脉粥样硬化之间存在因果关系。在 MVMR 分析中，在大多数模型中，PBC 对 T1D、HF、MI 和小血管缺血性中风保持独立影响：我们的研究结果揭示了 PBC 对糖尿病和 7 种心血管疾病的因果效应，但未发现 PBC 与冠状动脉粥样硬化之间存在因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinics and research in hepatology and gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.30

自引率

3.70%

发文量

198

审稿时长

42 days

期刊介绍： Clinics and Research in Hepatology and Gastroenterology publishes high-quality original research papers in the field of hepatology and gastroenterology. The editors put the accent on rapid communication of new research and clinical developments and so called "hot topic" issues. Following a clear Editorial line, besides original articles and case reports, each issue features editorials, commentaries and reviews. The journal encourages research and discussion between all those involved in the specialty on an international level. All articles are peer reviewed by international experts, the articles in press are online and indexed in the international databases (Current Contents, Pubmed, Scopus, Science Direct). Clinics and Research in Hepatology and Gastroenterology is a subscription journal (with optional open access), which allows you to publish your research without any cost to you (unless you proactively chose the open access option). Your article will be available to all researchers around the globe whose institution has a subscription to the journal.