Thrifty tissues prefer recycled purines over new-cleotides

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-07-11 DOI:10.1016/j.molcel.2024.06.015

David Sokolov, Lucas B. Sullivan

引用次数: 0

Abstract

In two recent studies appearing in Cell¹ and Cell Metabolism,² Tran et al. and Wu et al. describe underappreciated nuance in organismal and cellular purine nucleotide salvage pathways and identify purine salvage as a metabolic limitation for tumor growth.

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节俭的组织更喜欢回收的嘌呤而不是新的核苷酸

在最近发表于《细胞》1 和《细胞代谢》2 的两项研究中，Tran 等人和 Wu 等人描述了生物体和细胞嘌呤核苷酸挽救途径中被忽视的细微差别，并指出嘌呤挽救是肿瘤生长的代谢限制因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.

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