Respiratory Syncytial Virus: Biology, Genetic Diversity, and Perspective Control Preparations

IF 0.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Genetics, Microbiology and Virology Pub Date : 2024-07-09 DOI:10.3103/s0891416824700022

D. E. Maslov, I. D. Osipov, V. A. Vasikhovskaya, D. S. Zabelina, N. I. Meshcheryakov, M. Yu. Kartashov, S. E. Romanov, S. V. Netesov

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引用次数: 0

Abstract

Human respiratory syncytial virus (RSV) is an RNA virus of the family Pneumoviridae and is a common causative agent of acute respiratory infections. Infection with this virus is often severe and can result in fatalities and chronic complications, particularly in high-risk groups such as children under the age of 5 and elderly individuals over 65 years old. This review presents the latest data on the taxonomy, virion structure, and genome map of RSV, as well as its role in the etiology of acute respiratory diseases. We have analyzed over 100 publications on RSV genotyping in different parts of the world including Russia published between 2015 and 2023. The genetic composition of RSV isolates in Russia is similar to that in other regions of the world, which are predominantly represented by genotypes ON1 and BA9. The development of effective vaccines is crucial for successful disease control. The review summarizes global advances in the development of interventions against RSV, emphasizing promising treatments currently undergoing clinical trials and the ones that have recently been approved. Similar interventions (vaccines) are yet to be developed in Russia, but the similarities in genetic composition of RSV in Russia and worldwide offer hope for the rapid development of domestic vaccines against this infection.

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呼吸道合胞病毒：生物学、遗传多样性和前景控制制剂

人类呼吸道合胞病毒（RSV）是肺炎病毒科的一种 RNA 病毒，是急性呼吸道感染的常见病原体。感染这种病毒通常病情严重，可导致死亡和慢性并发症，尤其是在 5 岁以下儿童和 65 岁以上老人等高危人群中。本综述介绍了有关 RSV 的分类、病毒结构和基因组图谱的最新数据，以及它在急性呼吸道疾病病因学中的作用。我们分析了 2015 年至 2023 年期间在世界各地（包括俄罗斯）发表的 100 多篇有关 RSV 基因分型的论文。俄罗斯 RSV 分离物的基因组成与世界其他地区相似，主要以基因型 ON1 和 BA9 为代表。开发有效的疫苗对于成功控制疾病至关重要。本综述总结了全球在开发 RSV 干预措施方面取得的进展，重点介绍了目前正在进行临床试验的有前景的治疗方法以及最近获得批准的治疗方法。俄罗斯尚未开发出类似的干预措施（疫苗），但俄罗斯和全球 RSV 基因组成的相似性为迅速开发国内疫苗预防这种感染带来了希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Genetics, Microbiology and Virology BIOCHEMISTRY & MOLECULAR BIOLOGY-MICROBIOLOGY

CiteScore

0.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Molecular Genetics, Microbiology and Virology is a journal that covers most topical theoretical and applied problems of molecular genetics of pro- and eukaryotic organisms, molecular microbiology and molecular virology. An important part the journal assigns to investigations of the genetic apparatus of microorganisms, searching for forms of genetic exchange, genetic mapping of pathogenic causative agents, to ascertainment of the structure and functions of extrachromosomal factors of heredity and migratory genetic elements, to theoretical studies into the mechanisms of genetic regulation. The journal publishes results of research on molecular and genetic bases of an eukaryotic cell, functioning of chromosomes and chromatin, nature of genetic changes in malignization and a set of hereditary diseases. On the pages of the journal there is covered the formulation of molecular bases of virology including issues of integration of viral and cellular genomes, and issues of persistence. The journal plans to put materials on genetic engineering, envisaging synthesis and isolation of genes from natural reservoirs, creation of plasmid- and virus-based vector, production of recombinant DNA molecules, the creation of Gene Banks for Microbes, animals, and human; and also on biotechnological production of hormones, components of antiviral vaccines, diagnostic and therapeutic preparations.