{"title":"Biocatalysis in microfluidic systems: an experimental basis for data science†","authors":"John M. Woodley","doi":"10.1039/D3RE00703K","DOIUrl":null,"url":null,"abstract":"<p >Biocatalysis using (recombinant) enzymes is gaining traction as a method for selective chemical catalysis, especially in the pharmaceutical industry. Flow systems, especially miniaturized microfluidic systems, have proven to be a useful method to test new enzyme reaction sequences and processes. In this brief article, it will be argued that microfluidics not only can be used for rapid testing of reaction processes, but also can be used nowadays for collection of process data, especially for parameters in relevant kinetic and stability models, and thereby to help with scale-up, which remains a major challenge for implementation of biocatalysis in many industries. The ability to quickly change conditions (such as temperature) in microfluidic devices makes them ideally suited to such scale-down studies, and can form the experimental basis for data science as a tool for future process development.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reaction Chemistry & Engineering","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/re/d3re00703k","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Biocatalysis using (recombinant) enzymes is gaining traction as a method for selective chemical catalysis, especially in the pharmaceutical industry. Flow systems, especially miniaturized microfluidic systems, have proven to be a useful method to test new enzyme reaction sequences and processes. In this brief article, it will be argued that microfluidics not only can be used for rapid testing of reaction processes, but also can be used nowadays for collection of process data, especially for parameters in relevant kinetic and stability models, and thereby to help with scale-up, which remains a major challenge for implementation of biocatalysis in many industries. The ability to quickly change conditions (such as temperature) in microfluidic devices makes them ideally suited to such scale-down studies, and can form the experimental basis for data science as a tool for future process development.
期刊介绍:
Reaction Chemistry & Engineering is a new journal reporting cutting edge research into all aspects of making molecules for the benefit of fundamental research, applied processes and wider society.
From fundamental, molecular-level chemistry to large scale chemical production, Reaction Chemistry & Engineering brings together communities of chemists and chemical engineers working to ensure the crucial role of reaction chemistry in today’s world.