Association Between Gut and Nasal Microbiota and Allergic Rhinitis: A Systematic Review

IF 3.7 3区医学 Q2 ALLERGY

Journal of Asthma and Allergy Pub Date : 2024-07-09 DOI:10.2147/jaa.s472632

Yucheng Hu, Rong Zhang, Junjie Li, Huan Wang, Meiya Wang, Qiuyi Ren, Yueqi Fang, Li Tian

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Abstract

Abstract: Allergic rhinitis is a chronic non-infectious inflammation of the nasal mucosa mediated by specific IgE. Recently, the human microbiome has drawn broad interest as a potential new target for treating this condition. This paper succinctly summarizes the main findings of 17 eligible studies published by February 2024, involving 1044 allergic rhinitis patients and 954 healthy controls from 5 countries. These studies examine differences in the human microbiome across important mucosal interfaces, including the nasal and intestinal areas, between patients and controls. Overall, findings suggest variations in the gut microbiota between allergic rhinitis patients and healthy individuals, although the specific bacterial taxa that significantly changed were not always consistent across studies. Due to the limited scope of existing research and patient coverage, the relationship between the nasal microbiome and allergic rhinitis remains inconclusive. The article discusses the potential immune-regulating role of the gut microbiome in allergic rhinitis. Further well-designed clinical trials with large-scale recruitment of allergic rhinitis patients are encouraged.

Keywords: allergic rhinitis, microbiota dysbiosis, nasal microbiome, short-chain fatty acids, immunomodulation

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肠道和鼻腔微生物群与过敏性鼻炎的关系：系统性综述

摘要：过敏性鼻炎是由特异性 IgE 介导的鼻粘膜慢性非感染性炎症。最近，人类微生物组作为治疗这种疾病的潜在新靶点引起了广泛关注。本文简明扼要地总结了截至 2024 年 2 月发表的 17 项合格研究的主要发现，这些研究涉及来自 5 个国家的 1044 名过敏性鼻炎患者和 954 名健康对照者。这些研究考察了患者和对照组在鼻腔和肠道等重要粘膜界面上的人体微生物组差异。总体而言，研究结果表明，过敏性鼻炎患者和健康人的肠道微生物群存在差异，但不同研究中发生显著变化的具体细菌类群并不总是一致的。由于现有的研究范围和患者覆盖面有限，鼻腔微生物群与过敏性鼻炎之间的关系仍无定论。文章讨论了肠道微生物组在过敏性鼻炎中的潜在免疫调节作用。关键词：过敏性鼻炎；微生物群失调；鼻腔微生物群；短链脂肪酸；免疫调节

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来源期刊

Journal of Asthma and Allergy Medicine-Immunology and Allergy

CiteScore

5.30

自引率

6.20%

发文量

185

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal publishing original research, reports, editorials and commentaries on the following topics: Asthma; Pulmonary physiology; Asthma related clinical health; Clinical immunology and the immunological basis of disease; Pharmacological interventions and new therapies. Although the main focus of the journal will be to publish research and clinical results in humans, preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies.