Hypoxia-driven Dental Pulp Stem Cells as a Promising Strategy for Tissue Regeneration

IF 2.1 4区医学 Q4 CELL & TISSUE ENGINEERING

Current stem cell research & therapy Pub Date : 2024-07-05 DOI:10.2174/011574888x312892240625091241

Chengcheng Liao, Lulu Chen, Mingli Xiang, Sichen Long, Meiling Xiang, Linlin Xiao, Qian Long, Jianguo Liu, Xiaoyan Guan

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Abstract

: Hypoxia is a common hallmark in both physiological and pathological states. The adaptation to hypoxia is a key cellular event in the development and differentiation of stem cells, as well as in pathological conditions such as ischemia. The hypoxic microenvironment, culture conditions, and reactive oxygen species (ROS) scavengers have all been shown to enhance the proliferation, anti-aging properties, immunomodulatory capabilities, differentiation potential, and regenerative and therapeutic potential of dental pulp stem cells (DPSCs). However, severe and persistent hypoxia can be detrimental to the survival and tissue regeneration of DPSCs. Therefore, hypoxic preconditioning of DPSCs and applying oxygen-releasing materials to mitigate extreme hypoxia can enhance the regenerative and therapeutic potential in damaged organisms. This article provides a comprehensive review of the influence of the hypoxic microenvironment on the biological characteristics of dental pulp stem cells (DPSCs). It also presents a summary of the recent research advances in DPSCs regarding tissue regeneration, particularly focusing on the utilization of hypoxic preconditioning. Additionally, this review highlights the diverse biological effects of hypoxia on tissue regeneration and proposes promising novel therapeutic strategies.

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缺氧驱动的牙髓干细胞是一种前景广阔的组织再生策略

:缺氧是生理和病理状态的共同特征。在干细胞的发育和分化过程中，以及在缺血等病理状态下，对缺氧的适应是一个关键的细胞事件。缺氧微环境、培养条件和活性氧（ROS）清除剂都被证明能增强牙髓干细胞（DPSCs）的增殖、抗衰老特性、免疫调节能力、分化潜力、再生和治疗潜力。然而，严重和持续的缺氧会损害牙髓干细胞的存活和组织再生。因此，对DPSCs进行缺氧预处理，并应用释放氧气的材料来缓解极度缺氧，可提高受损生物的再生和治疗潜力。本文全面综述了缺氧微环境对牙髓干细胞（DPSCs）生物学特性的影响。文章还总结了牙髓干细胞在组织再生方面的最新研究进展，尤其侧重于缺氧预处理的利用。此外，这篇综述还强调了缺氧对组织再生的各种生物效应，并提出了有前景的新型治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current stem cell research & therapy CELL & TISSUE ENGINEERING-CELL BIOLOGY

CiteScore

4.20

自引率

3.70%

发文量

197

审稿时长

>12 weeks

期刊介绍： Current Stem Cell Research & Therapy publishes high quality frontier reviews, drug clinical trial studies and guest edited issues on all aspects of basic research on stem cells and their uses in clinical therapy. The journal is essential reading for all researchers and clinicians involved in stem cells research.