Multidimensionally Nano-topologized Polycaprolactone Fibrous Membrane Anchored with Bimetallic Peroxide Nanodots for Microenvironment-Switched Treatment on Infected Diabetic Wounds

IF 17.2 1区 工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Lin Qi, Yong Huang, Zheng Liu, Jiangshan Liu, Jing Wang, Huilun Xu, Hao Yang, Limin Liu, Ganjun Feng, Shuyu Zhang, Yubao Li, Li Zhang
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Abstract

Delayed healing of diabetic wounds poses a major challenge to human health due to severe vascular dysfunction, sustained inflammation, and vulnerability to microbial infection. Herein, we constructed multidimensionally nano-topologized electrospun polycaprolactone (PCL) fibrous membranes with shish-kebab nanoarrays on each fiber through self-induced crystallization, on which the CuO2–MgO2 bimetallic peroxide nanodots (BPNs) were anchored by polydopamine (PDA) as the bridging layer. When activated by the acidic microenvironment (typically infected diabetic wound), BPNs on fibers reacted immediately to release Cu2+ and Mg2+ ions together with hydrogen peroxide (H2O2) molecules, which were then transferred into ·OH radicals through Fenton-type reactions catalyzed by Cu2+ for instant bacteria elimination. At the same time, the released Cu2+ and Mg2+ ions were retained to improve the angiogenesis and suppress the inflammation infiltration, thus remodeling the wound microenvironment. Meanwhile, the one-dimensional (1D)-constructed nano shish-kebabs and PDA coating on fibers provided additional topological activation for cell adhesion and directed migration along the aligned fiber orientation. Through the meticulous design, the resultant membranes markedly accelerated the infected wound healing in the diabetic rat model. This study pioneers a unique design to develop a nanocomposite fibrous membrane that combines multidimensional topologies with chemodynamic therapy (CDT), for efficiently combating infected diabetic wounds.

Graphical abstract

Abstract Image

用双金属过氧化物纳米点锚定的多维纳米拓扑化聚己内酯纤维膜,用于感染性糖尿病伤口的微环境切换治疗
由于严重的血管功能障碍、持续的炎症和易受微生物感染,糖尿病伤口的延迟愈合对人类健康构成了重大挑战。在这里,我们通过自诱导结晶构建了多维纳米拓扑化的电纺聚己内酯(PCL)纤维膜,每根纤维上都有什刹海纳米阵列,其上以聚多巴胺(PDA)为桥层锚定了CuO2-MgO2双金属过氧化物纳米点(BPNs)。当被酸性微环境(典型的糖尿病感染伤口)激活时,纤维上的 BPNs 会立即发生反应,释放出 Cu2+ 和 Mg2+ 离子以及过氧化氢(H2O2)分子,然后通过 Cu2+ 催化的 Fenton 型反应转化为 -OH 自由基,从而瞬间消灭细菌。同时,释放的 Cu2+ 和 Mg2+ 离子被保留下来,改善血管生成,抑制炎症浸润,从而重塑伤口微环境。同时,纤维上的一维(1D)纳米串珠和 PDA 涂层为细胞粘附提供了额外的拓扑激活,并引导细胞沿排列整齐的纤维方向迁移。通过精心设计,所制成的膜明显加快了糖尿病大鼠模型感染伤口的愈合。这项研究开创性地设计开发了一种纳米复合纤维膜,它将多维拓扑结构与化学动力疗法(CDT)相结合,可有效防治糖尿病感染性伤口。
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来源期刊
CiteScore
18.70
自引率
11.20%
发文量
109
期刊介绍: Advanced Fiber Materials is a hybrid, peer-reviewed, international and interdisciplinary research journal which aims to publish the most important papers in fibers and fiber-related devices as well as their applications.Indexed by SCIE, EI, Scopus et al. Publishing on fiber or fiber-related materials, technology, engineering and application.
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