Harnessing acetogenic bacteria for one-carbon valorization toward sustainable chemical production

IF 4.2 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jiyun Bae, Chanho Park, Hyunwoo Jung, Sangrak Jin and Byung-Kwan Cho
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Abstract

The pressing climate change issues have intensified the need for a rapid transition towards a bio-based circular carbon economy. Harnessing acetogenic bacteria as biocatalysts to convert C1 compounds such as CO2, CO, formate, or methanol into value-added multicarbon chemicals is a promising solution for both carbon capture and utilization, enabling sustainable and green chemical production. Recent advances in the metabolic engineering of acetogens have expanded the range of commodity chemicals and biofuels produced from C1 compounds. However, producing energy-demanding high-value chemicals on an industrial scale from C1 substrates remains challenging because of the inherent energetic limitations of acetogenic bacteria. Therefore, overcoming this hurdle is necessary to scale up the acetogenic C1 conversion process and realize a circular carbon economy. This review overviews the acetogenic bacteria and their potential as sustainable and green chemical production platforms. Recent efforts to address these challenges have focused on enhancing the ATP and redox availability of acetogens to improve their energetics and conversion performances. Furthermore, promising technologies that leverage low-cost, sustainable energy sources such as electricity and light are discussed to improve the sustainability of the overall process. Finally, we review emerging technologies that accelerate the development of high-performance acetogenic bacteria suitable for industrial-scale production and address the economic sustainability of acetogenic C1 conversion. Overall, harnessing acetogenic bacteria for C1 valorization offers a promising route toward sustainable and green chemical production, aligning with the circular economy concept.

Abstract Image

利用醋酸菌进行单碳估值,实现可持续化学品生产
迫在眉睫的气候变化问题加剧了向以生物为基础的循环碳经济快速过渡的必要性。利用醋酸菌作为生物催化剂,将二氧化碳、一氧化碳、甲酸或甲醇等 C1 化合物转化为高附加值的多碳化学品,是碳捕获和碳利用的一个前景广阔的解决方案,可实现可持续的绿色化学品生产。最近在醋酸菌代谢工程方面取得的进展扩大了利用 C1 化合物生产商品化学品和生物燃料的范围。然而,由于醋酸菌固有的能量限制,在工业规模上利用 C1 底物生产高能量需求的高价值化学品仍具有挑战性。因此,要扩大醋酸菌 C1 转化过程的规模并实现循环碳经济,就必须克服这一障碍。本综述概述了醋酸菌及其作为可持续绿色化学品生产平台的潜力。近期为应对这些挑战所做的努力主要集中在提高醋酸菌的 ATP 和氧化还原可用性,以改善其能量学和转化性能。此外,我们还讨论了利用低成本、可持续能源(如电能和光能)提高整个过程可持续性的前景广阔的技术。最后,我们回顾了加速开发适合工业规模生产的高性能醋酸菌的新兴技术,并探讨了醋酸 C1 转化的经济可持续性问题。总之,利用醋酸菌进行 C1 价值化为实现可持续的绿色化工生产提供了一条大有可为的途径,符合循环经济的理念。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.10
自引率
0.00%
发文量
128
审稿时长
10 weeks
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