Systemic immune-inflammatory index and systemic inflammation response index in predicting renal impairment in children with type 1 diabetes mellitus

IF 0.5 Q4 PEDIATRICS

Egyptian Pediatric Association Gazette Pub Date : 2024-07-08 DOI:10.1186/s43054-024-00290-2

Rehab Elmeazawy, Sarah El Shall, Manal Zaki AbdElsamea, Mohammed Helmi Emara

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Abstract

The aim of this study was to investigate the role of systemic immune-inflammatory index and systemic inflammation response index in predicting early renal impairment in children with type 1 diabetes mellitus (T1DM). This is a retrospective cohort study which searched the electronic medical records of patients consecutively admitted to Pediatric Endocrinology Unit with the diagnosis of type 1 diabetes mellitus between August 2022 and July 2023. A total of 100 children with the diagnosis of T1DM were enrolled in the study. Early stage diabetic nephropathy (DN) was found in 34 patients. Patients with DN showed significantly higher HbA1C, microalbuminuria, cholesterol, TLC, platelet, neutrophil count, NLR, PLR, SII, and SIRI than the DM without DN. It was discovered that DN was independently correlated with NLR, PLR, SII, and SIRI. SIRI and SII are easily available and affordable inflammatory markers that may serve as independent early predictors of diabetic nephropathy in individuals with type 1 diabetes.

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预测 1 型糖尿病儿童肾功能损害的全身免疫炎症指数和全身炎症反应指数

本研究旨在探讨全身免疫炎症指数和全身炎症反应指数在预测1型糖尿病（T1DM）儿童早期肾功能损害中的作用。这是一项回顾性队列研究，研究人员检索了2022年8月至2023年7月期间儿科内分泌科连续收治的诊断为1型糖尿病患者的电子病历。共有100名确诊为T1DM的儿童参与了研究。34名患者发现了早期糖尿病肾病（DN）。DN患者的HbA1C、微量白蛋白尿、胆固醇、TLC、血小板、中性粒细胞计数、NLR、PLR、SII和SIRI均明显高于无DN的DM患者。研究发现，DN 与 NLR、PLR、SII 和 SIRI 存在独立相关性。SIRI 和 SII 是容易获得且价格低廉的炎症标志物，可作为 1 型糖尿病患者糖尿病肾病的独立早期预测指标。

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来源期刊

Egyptian Pediatric Association Gazette PEDIATRICS-

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： The Gazette is the official journal of the Egyptian Pediatric Association. The main purpose of the Gazette is to provide a place for the publication of high-quality papers documenting recent advances and new developments in both pediatrics and pediatric surgery in clinical and experimental settings. An equally important purpose of the Gazette is to publish local and regional issues related to children and child care. The Gazette welcomes original papers, review articles, case reports and short communications as well as short technical reports. Papers submitted to the Gazette are peer-reviewed by a large review board. The Gazette also offers CME quizzes, credits for which can be claimed from either the EPA website or the EPA headquarters. Fields of interest: all aspects of pediatrics, pediatric surgery, child health and child care. The Gazette complies with the Uniform Requirements for Manuscripts submitted to biomedical journals as recommended by the International Committee of Medical Journal Editors (ICMJE).