Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?

World journal of methodology Pub Date : 2024-06-20 DOI:10.5662/wjm.v14.i2.89284

Serafeim-Chrysovalantis Kotoulas, Kalliopi Domvri, Alexandros Tsantos, Ioanna Papagiouvanni, Anastasia Michailidou, Dionisios G Spyratos, Konstantinos Porpodis, Ioanna Grigoriou, Despina Papakosta, Athanasia Pataka

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Abstract

Background: Electronic cigarettes (ECs) have been promoted as alternatives to traditional cigarettes.

Aim: To investigate ECs' effects on respiratory system, especially in patients with respiratory diseases.

Methods: We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy smokers. All were subjucted to pulmonary function tests (PFTs), impulse oscillometry (IOS), fraction exhaled Nitric Oxide (FeNO), exhaled breathe condensate (EBC) and biomarker measurements before and after vaping one nicotine-containing EC.

Results: The increase in FeNO 30 minutes after EC, reflecting airway inflammation, significantly correlated with increase of residual volume (RV), total lung capacity, respiratory impedance at 5 Hz (Z5Hz) and respiratory resistance at 5 and 20 Hz (R5Hz and R20Hz). No significant correlations were found between EBC biomarkers' changes and respiratory mechanics.

Conclusion: This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.

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哮喘患者吸食电子烟后气道炎症的变化与呼吸力学的变化之间是否存在相关性？

背景：电子香烟（ECs）作为传统香烟的替代品已得到推广：目的：研究电子香烟对呼吸系统的影响，尤其是对呼吸系统疾病患者的影响：我们随机挑选了 25 名患有稳定中度哮喘的吸烟者，并将他们与 25 名健康吸烟者配对。所有吸烟者在吸食含尼古丁的电子烟前后均接受了肺功能测试（PFTs）、脉冲振荡计（IOS）、呼出一氧化氮分数（FeNO）、呼出冷凝物（EBC）和生物标志物测量：结果：吸入尼古丁电子镇静剂 30 分钟后，反映气道炎症的 FeNO 增加与残余容积（RV）、总肺活量、5 赫兹呼吸阻抗（Z5Hz）以及 5 赫兹和 20 赫兹呼吸阻力（R5Hz 和 R20Hz）的增加显著相关。EBC生物标志物的变化与呼吸力学之间没有发现明显的相关性：这是首次研究表明，EC 引起的气道炎症变化对哮喘患者的呼吸力学有直接影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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World journal of methodology

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