Association between tobacco exposure and bladder cancer recurrence: A systematic review and meta-analysis.

Lei Xiang, Qi-Qi Xie, Si-Si Xu, Wen-Jie Ruan, Dong-Hui Xu, Yao-Yao Gan, Jia Zuo, Wen-Jun Xu, Zhi-Peng Li
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Abstract

Background: However, the connection between smoking and the prognosis of patients with bladder cancer remains unclear.

Aim: To determine whether smoking is linked to the recurrence and progression of bladder cancer.

Methods: As of July 20, 2022, relevant English-language research was identified by searching PubMed, the Web of Science, and the Cochrane Library. We pooled the available data from the included studies using a random effects model. Subgroup analysis and sensitivity analysis were also conducted.

Results: A total of 12 studies were included in this meta-analysis. The combined analysis revealed that tobacco exposure was associated with a significantly greater recurrence rate than nonsmoking status [odd ratios (OR) = 1.76, 95%CI: 1.84-2.93], and the progression of bladder cancer was significantly greater in smokers than in nonsmokers (OR = 1.21, 95%CI: 1.02-1.44). Stratified analysis further revealed that current smokers were more likely to experience relapse than never-smokers were (OR = 1.85, 95%CI: 1.11-3.07). Former smokers also had a greater risk of relapse than did never-smokers (OR = 1.73, 95%CI: 1.09-2.73). Subgroup analysis indicated that non-Caucasians may be more susceptible to bladder cancer recurrence than Caucasians are (OR = 2.13, 95%CI: 1.74-2.61).

Conclusion: This meta-analysis revealed that tobacco exposure may be a significant risk factor for both the recurrence and progression of bladder cancer.

烟草暴露与膀胱癌复发之间的关系:系统回顾和荟萃分析。
背景:吸烟与膀胱癌患者的预后之间的关系尚不清楚:目的:确定吸烟是否与膀胱癌的复发和进展有关:截至 2022 年 7 月 20 日,通过搜索 PubMed、Web of Science 和 Cochrane Library,我们找到了相关的英文研究。我们采用随机效应模型对纳入研究的可用数据进行了汇总。我们还进行了分组分析和敏感性分析:本荟萃分析共纳入了 12 项研究。综合分析表明,烟草暴露与复发率明显高于非吸烟状态相关[奇数比(OR)= 1.76,95%CI:1.84-2.93],吸烟者的膀胱癌进展明显高于非吸烟者(OR = 1.21,95%CI:1.02-1.44)。分层分析进一步显示,当前吸烟者比从不吸烟者更容易复发(OR = 1.85,95%CI:1.11-3.07)。曾经吸烟者的复发风险也高于从未吸烟者(OR = 1.73,95%CI:1.09-2.73)。亚组分析表明,非白种人可能比白种人更容易复发膀胱癌(OR = 2.13,95%CI:1.74-2.61):这项荟萃分析表明,烟草暴露可能是膀胱癌复发和进展的重要风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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