The Revised Reflux Symptom Index (R-RSI): Development, Internal and External Validation Study.

IF 1.1 4区 医学 Q3 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY
Andrea Nacci, Nicola de Bortoli, Silvia Capobianco, Federica Simoni, Tamanai Giusti, Pierfrancesco Visaggi, Maria Rosaria Barillari, Edoardo Vincenzo Savarino, Marzio Frazzoni, Stefano Berrettini, Bruno Fattori, Luca Bastiani
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引用次数: 0

Abstract

Introduction: This study proposes a revised version of the Reflux Symptom Index (R-RSI), a seventeen-item questionnaire that was revised to increase the suspicion of laryngopharyngeal reflux disease (LPRD).

Methods: Internal validation involved 213 participants, comprising 160 subjects without a previous LPRD diagnosis and 53 subjects with a self-reported previous diagnosis of LPRD with or without gastroesophageal reflux disease (GERD). Test-retest reliability and internal consistency were calculated. For the external validation, 56 patients (independent from the previous cohort) were enrolled to explore the R-RSI screening properties and determine a cutoff using 24-h MII-pH as the gold standard.

Results: R-RSI test-retest reliability was high, both for the total score (ICC: 0.970) and for each item (ranging from 0.876 to 0.980). Cronbach's alpha was 0.910, indicating excellent internal consistency of the questionnaire. Participants with a previous self-reported diagnosis scored significantly higher (mean 24.94 ± 7.4; median 26, IQR 20-29) than those without a previous diagnosis (mean 4.66 ± 5.3; median 4, IQR 1-6) (p value <0.0001). Participants with both previous LPRD and GERD diagnoses had higher scores (27.20 ± 7.8) compared to those with only LPRD (21.77 ± 5.5) (p value = 0.003). Using 24-h MII-pH diagnosis as a gold standard, the optimal R-RSI cutoff point was determined to be 18, with a sensitivity of 84.5% and a specificity of 81.8%, positive predictive value of 95%, and negative predictive value of 60%.

Conclusions: Our results suggest that the R-RSI may be useful to suspect LPRD, with or without GERD. The R-RSI is a self-administered patient-reported outcome questionnaire that demonstrates excellent reliability and high screening properties. Employing a cutoff of ≥18 in the R-RSI can assist in diagnosing and monitoring LPRD.

修订版反流症状指数(R-RSI):开发、内部和外部验证研究。
简介本研究提出了反流症状指数(R-RSI)的修订版,这是一份包含十七个项目的调查问卷,经修订后可增加对喉咽反流病(LPRD)的怀疑:方法:对 213 名参与者进行了内部验证,其中包括 160 名既往未确诊 LPRD 的受试者和 53 名自述既往确诊 LPRD 并伴有或不伴有胃食管反流病(GERD)的受试者。计算了重测可靠性和内部一致性。为了进行外部验证,共招募了 56 名患者(独立于之前的队列),以探索 R-RSI 筛选特性,并以 24 小时 MII-pH 作为金标准来确定临界值:总分(ICC:0.970)和每个项目(从 0.876 到 0.980)的 R-RSI 测试再测可靠性都很高。Cronbach's alpha 为 0.910,表明问卷具有良好的内部一致性。曾有过自我诊断的受试者的得分(平均值为 24.94 ± 7.4;中位数为 26,IQR 为 20-29)明显高于没有自我诊断的受试者(平均值为 4.66 ± 5.3;中位数为 4,IQR 为 1-6)(P 值为 0.0001)。与仅有 LPRD(21.77 ± 5.5)的参与者相比,既有 LPRD 诊断又有 GERD 诊断的参与者得分更高(27.20 ± 7.8)(p 值=0.003)。以 24 小时 MII-pH 诊断作为金标准,R-RSI 的最佳临界点被确定为 18,灵敏度为 84.5%,特异度为 81.8%,阳性预测值为 95%,阴性预测值为 60%:我们的研究结果表明,R-RSI 可用于怀疑伴有或不伴有胃食管反流病的 LPRD。R-RSI 是一种自填式患者报告结果问卷,具有极佳的可靠性和较高的筛查性能。将 R-RSI 的临界值设定为≥18,有助于诊断和监测 LPRD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Folia Phoniatrica et Logopaedica
Folia Phoniatrica et Logopaedica AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-OTORHINOLARYNGOLOGY
CiteScore
2.30
自引率
10.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Published since 1947, ''Folia Phoniatrica et Logopaedica'' provides a forum for international research on the anatomy, physiology, and pathology of structures of the speech, language, and hearing mechanisms. Original papers published in this journal report new findings on basic function, assessment, management, and test development in communication sciences and disorders, as well as experiments designed to test specific theories of speech, language, and hearing function. Review papers of high quality are also welcomed.
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