Selective decontamination of the digestive tract in burn patients: Protocol for a systematic review.

IF 1.9 4区 医学 Q2 ANESTHESIOLOGY
Acta Anaesthesiologica Scandinavica Pub Date : 2024-11-01 Epub Date: 2024-07-09 DOI:10.1111/aas.14498
Emma Atsuko Tsuchiya, Jacob Jensen-Abbew, Mette Krag, Morten Hylander Møller, Martin Risom Vestergaard, Christian Overgaard-Steensen, Marie Helleberg, Rikke Holmgaard, Johan Heiberg
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引用次数: 0

Abstract

Background: Nosocomial infections contribute significantly to mortality and morbidity in burn patients. Selective decontamination of the digestive tract is an infection prevention measure that has been shown to improve survival in mechanically ventilated intensive care unit (ICU) patients. It has been hypothesized that burn patients may benefit from selective decontamination of the digestive tract.

Methods/design: We will conduct a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials (RCTs) assessing the patient-important effects of selective decontamination of the digestive tract in burn patients, as compared with placebo or no intervention/standard of care. The primary outcome will be 30-day mortality. Secondary outcomes include serious adverse events, anti-microbial resistance, pneumonia, blood stream infections, ICU- and hospital-free days and 90-day mortality. We will search the following databases: CENTRAL, MEDLINE, EMBASE, BIOSIS, Web of Science and CINAHL and follow the recommendations provided by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The certainty of evidence will be assessed according to the GRADE approach: Grading of Recommendations Assessment, Development and Evaluation.

Discussion: There is clinical equipoise about the use of selective decontamination of the digestive tract in burn patients. In the outlined systematic review and meta-analysis, we will assess the desirable and undesirable effects of selective decontamination of the digestive tract in burn patients.

烧伤病人消化道的选择性净化:系统综述协议。
背景:烧伤患者的死亡率和发病率与非医院感染有很大关系。对消化道进行选择性净化是一种预防感染的措施,已被证明可提高机械通气重症监护室(ICU)患者的存活率。据推测,烧伤患者可能会从消化道选择性净化中获益:我们将对随机临床试验(RCT)进行系统回顾、荟萃分析和试验序列分析,评估与安慰剂或无干预/标准护理相比,选择性消化道净化对烧伤患者的重要影响。主要结果是 30 天死亡率。次要结果包括严重不良事件、抗微生物耐药性、肺炎、血流感染、重症监护室和无住院日以及 90 天死亡率。我们将搜索以下数据库:CENTRAL、MEDLINE、EMBASE、BIOSIS、Web of Science 和 CINAHL。证据的确定性将根据 GRADE 方法进行评估:讨论:临床上对烧伤患者消化道选择性净化的使用存在分歧。在概述的系统综述和荟萃分析中,我们将评估烧伤患者消化道选择性净化的理想和不理想效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.30
自引率
9.50%
发文量
157
审稿时长
3-8 weeks
期刊介绍: Acta Anaesthesiologica Scandinavica publishes papers on original work in the fields of anaesthesiology, intensive care, pain, emergency medicine, and subjects related to their basic sciences, on condition that they are contributed exclusively to this Journal. Case reports and short communications may be considered for publication if of particular interest; also letters to the Editor, especially if related to already published material. The editorial board is free to discuss the publication of reviews on current topics, the choice of which, however, is the prerogative of the board. Every effort will be made by the Editors and selected experts to expedite a critical review of manuscripts in order to ensure rapid publication of papers of a high scientific standard.
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