Immune cell triads reprogram exhausted CD8+ T cells for effective tumor elimination

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-07-08 DOI:10.1016/j.ccell.2024.06.010

Veronica Lise, Ines Malenica, Rahul Roychoudhuri, Enrico Lugli

引用次数: 0

Abstract

In this issue of Cancer Cell, Espinosa-Carrasco et al. show that the efficacy of cancer immunotherapies depends upon the formation of intratumoral immune triads between antigen-presenting cells and antigen-specific CD4⁺ and CD8⁺ T cells. This interaction reprograms tumor-specific CD8⁺ T cells to exert potent effector functions and eradicate established solid tumors.

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免疫细胞三元组对衰竭的 CD8+ T 细胞进行重编程，从而有效消除肿瘤

在本期《癌细胞》（Cancer Cell）杂志上，Espinosa-Carrasco 等人的研究表明，癌症免疫疗法的疗效取决于抗原递呈细胞与抗原特异性 CD4+ 和 CD8+ T 细胞之间形成的瘤内免疫三联体。这种相互作用使肿瘤特异性 CD8+ T 细胞重新编程，从而发挥强大的效应功能，根除已形成的实体瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.