The Analgesic Effect of a Transdermal Lappaconitine Patch Combined With Ibuprofen Suspension for Children After Adenoidectomy and Tonsillectomy: A Randomized Clinical Trial

IF 1.6 4区医学 Q2 NURSING

Journal of Perianesthesia Nursing Pub Date : 2025-02-01 DOI:10.1016/j.jopan.2024.03.025

Jiayuan Xu ADN, RN, CNOR , Min Wu BSN, RN, CAPA , Bo Duan MM, Yihua Ni MM, Anken Wang MM

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引用次数: 0

Abstract

Purpose

To study the analgesic effects and side effects of a transdermal lappaconitine (TLA) patch, ibuprofen suspension (IS), and TLA combined with IS (TLACIS) after adenoidectomy and tonsillectomy.

Design

Prospective, randomized clinical trial.

Methods

The patients were randomized into three groups defined by different analgesic drug regimens: the TLA group, the IS group, and the TLACIS group. Pain scores at 2, 12, and 24 hours after surgery and adverse-event reports within the first postoperative week were collected.

Results

Ultimately, this study included 102 cases in the TLA group, 101 cases in the IS group, and 101 cases in the TLACIS group. At 2 hours after surgery, the pain scores of the TLA and the TLACIS groups were both significantly lower than that of the IS group (all P < .05). At 12 and 24 hours after surgery, the pain score of the TLACIS group was significantly lower than those of the TLA and IS groups (all P < .05); furthermore, the pain score of the IS group was significantly lower than that of the TLA group (P < .05). Within 1 week after the operation, there was no significant difference in the incidence of adverse events.

Conclusions

The addition of a TLA patch can speed the onset of analgesia. In terms of analgesic effects, IS alone is more advantageous than TLA alone, while the combination of TLA and IS has the best analgesic effect. No significant differences were found in the incidence of adverse events among the three regimens.

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儿童腺样体切除术和扁桃体切除术后透皮拉帕康尼汀贴片联合布洛芬混悬液的镇痛效果：随机临床试验。

目的：研究腺样体切除术和扁桃体切除术后透皮拉帕康尼汀（TLA）贴片、布洛芬混悬液（IS）和TLA联合IS（TLACIS）的镇痛效果和副作用：设计：前瞻性随机临床试验：将患者随机分为三组，即 TLA 组、IS 组和 TLACIS 组。收集术后 2、12 和 24 小时的疼痛评分以及术后一周内的不良事件报告：最终，TLA 组有 102 例，IS 组有 101 例，TLACIS 组有 101 例。术后 2 小时时，TLA 组和 TLACIS 组的疼痛评分均明显低于 IS 组（均为 P 结论：TLA 贴片可以减轻患者的疼痛：添加 TLA 贴片可加快镇痛的开始。就镇痛效果而言，单独使用 IS 比单独使用 TLA 更有优势，而 TLA 和 IS 组合的镇痛效果最好。三种治疗方案的不良反应发生率无明显差异。

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来源期刊

Journal of Perianesthesia Nursing NURSING-

CiteScore

2.20

自引率

17.60%

发文量

279

审稿时长

90 days

期刊介绍： The Journal of PeriAnesthesia Nursing provides original, peer-reviewed research for a primary audience that includes nurses in perianesthesia settings, including ambulatory surgery, preadmission testing, postanesthesia care (Phases I and II), extended observation, and pain management. The Journal provides a forum for sharing professional knowledge and experience relating to management, ethics, legislation, research, and other aspects of perianesthesia nursing.