Artesunate inhibits vasculogenic mimicry in choroidal melanoma through HIF-1 α/ VEGF/PDGF pathway

IF 2.3 4区生物学 Q4 CELL BIOLOGY

Acta histochemica Pub Date : 2024-07-07 DOI:10.1016/j.acthis.2024.152174

Qing-yue Ma , Xiao-yan Xu , Yuan-zhang Zhu, Ning-ning Yao, Yi-chong Liu, Xiao-di Gao, Qian Zhang, Wen-juan Luo

引用次数: 0

Abstract

Choroidal melanoma (CM), a highly metastatic eye tumor, exhibits vasculogenic mimicry (VM) facilitated by hypoxia-induced angiogenesis. This study explored the inhibitory impact of the anti-malarial drug Artesunate (ART) on CM VM through modulation of the HIF-1α/VEGF/PDGF pathway. Immunohistochemistry (IHC) confirmed VM in CM with elevated VEGF and PDGF expression. Hypoxia promoted CM proliferation, upregulating HIF-1α, VEGF and PDGF. VEGF and PDGF enhanced CM migration, invasion and VM, with HIF-1α playing a crucial role. ART mitigated VM formation by suppressing the HIF-1α/VEGF/PDGF pathway, highlighting its potential as an anti-tumor agent in CM.

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青蒿琥酯通过HIF-1 α/ VEGF/PDGF途径抑制脉络膜黑色素瘤的血管生成模拟。

脉络膜黑色素瘤（CM）是一种高度转移性眼部肿瘤，在缺氧诱导的血管生成作用下表现出血管生成模拟（VM）。本研究探讨了抗疟疾药物青蒿琥酯（ART）通过调节 HIF-1α/VEGF/PDGF 通路对 CM VM 的抑制作用。免疫组化（IHC）证实了血管内皮生长因子（VEGF）和表皮生长因子（PDGF）表达升高的 CM 中的血管瘤。缺氧促进了 CM 的增殖，上调了 HIF-1α、VEGF 和 PDGF。VEGF 和 PDGF 增强了 CM 的迁移、侵袭和 VM，其中 HIF-1α 起着关键作用。ART通过抑制HIF-1α/VEGF/PDGF通路缓解了VM的形成，突出了其作为CM抗肿瘤药物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta histochemica 生物-细胞生物学

CiteScore

4.60

自引率

4.00%

发文量

107

审稿时长

23 days

期刊介绍： Acta histochemica, a journal of structural biochemistry of cells and tissues, publishes original research articles, short communications, reviews, letters to the editor, meeting reports and abstracts of meetings. The aim of the journal is to provide a forum for the cytochemical and histochemical research community in the life sciences, including cell biology, biotechnology, neurobiology, immunobiology, pathology, pharmacology, botany, zoology and environmental and toxicological research. The journal focuses on new developments in cytochemistry and histochemistry and their applications. Manuscripts reporting on studies of living cells and tissues are particularly welcome. Understanding the complexity of cells and tissues, i.e. their biocomplexity and biodiversity, is a major goal of the journal and reports on this topic are especially encouraged. Original research articles, short communications and reviews that report on new developments in cytochemistry and histochemistry are welcomed, especially when molecular biology is combined with the use of advanced microscopical techniques including image analysis and cytometry. Letters to the editor should comment or interpret previously published articles in the journal to trigger scientific discussions. Meeting reports are considered to be very important publications in the journal because they are excellent opportunities to present state-of-the-art overviews of fields in research where the developments are fast and hard to follow. Authors of meeting reports should consult the editors before writing a report. The editorial policy of the editors and the editorial board is rapid publication. Once a manuscript is received by one of the editors, an editorial decision about acceptance, revision or rejection will be taken within a month. It is the aim of the publishers to have a manuscript published within three months after the manuscript has been accepted