The useful lean tissue and appendicular skeletal muscle mass indices related to physical performance in patients undergoing hemodialysis

IF 0.6 4区医学 Q4 ENGINEERING, BIOMEDICAL

Isokinetics and Exercise Science Pub Date : 2024-06-21 DOI:10.3233/ies-230142

Yan Song, Xuanrui Zhang, Jianxia Lu

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引用次数: 0

Abstract

BACKGROUND: Low muscle quantity commonly seen in patients undergoing hemodialysis (HD) is the key contributor of declined physical performance and increases the risk of morbidity and mortality. However, how to normalize muscle mass for operational criteria in this population remains unknown. OBJECTIVE: To identify the clinically useful whole body lean tissue mass (LTM) and appendicular skeletal muscle mass (ASM) indices pertinent to physical performance in patients undertaking HD. METHODS: Whole body LTM in 38 and ASM in 22 patients undergoing HD were measured by body composition monitor (BCM) and dual-energy X-ray absorptiometry (DXA), respectively. Physical performance was assessed by handgrip strength, the incremental shuttle walk test, sit-to-stand tests, gait speed, Short Physical Performance Battery and Duke Activity Status Index. Besides crude LTM and ASM, the other muscle indices were utilized normalizing for height, height squared, weight, body mass index (BMI), fat mass and body fat%. RESULTS: Regardless of BCM or DXA being used, the relationships between different muscle mass indices and physical function were not consistent. While the most useful LTM index which was strongly associated with physical function involved adjustment for height, the strongest (and most useful) ASM index was normalization for BMI. CONCLUSION: The superiority of adjustment for BMI or height (height2) recommended by international sarcopenia consensus is also suitable for patients undergoing HD. Patients’ BMI or fat mass should be considered in estimating prevalence of sarcopenia and evaluating relationship between muscle mass and physical performance.

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与血液透析患者体能表现相关的有用瘦肉组织和骨骼肌质量指标

背景：血液透析（HD）患者中常见的低肌肉量是导致体能下降的主要原因，并增加了发病和死亡的风险。然而，如何使这一人群的肌肉质量符合操作标准仍是未知数。目的：确定与血液透析患者体能表现相关的、对临床有用的全身瘦肉组织质量（LTM）和附属骨骼肌质量（ASM）指数。方法：通过身体成分监测仪（BCM）和双能 X 射线吸收测量仪（DXA）分别测量了 38 名接受血液透析患者的全身瘦肉组织质量（LTM）和 22 名接受血液透析患者的骨骼肌质量（ASM）。体能通过手握强度、增量穿梭步行测试、坐立测试、步速、短期体能测试和杜克活动状态指数进行评估。除了粗LTM和ASM外，其他肌肉指数也根据身高、身高平方、体重、体重指数（BMI）、脂肪量和体脂率进行了归一化处理。结果：无论使用 BCM 还是 DXA，不同肌肉质量指数与身体功能之间的关系并不一致。与身体功能密切相关的最有用的 LTM 指数涉及身高调整，而最强（也是最有用）的 ASM 指数是体重指数正常化。结论：国际肌肉疏松症共识推荐的调整体重指数或身高（身高2）的优越性也适用于接受 HD 治疗的患者。在估计肌肉疏松症的患病率及评估肌肉质量与体能表现之间的关系时，应考虑患者的体重指数或脂肪量。

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来源期刊

Isokinetics and Exercise Science 医学-工程：生物医学

CiteScore

1.20

自引率

14.30%

发文量

审稿时长

>12 weeks

期刊介绍： Isokinetics and Exercise Science (IES) is an international journal devoted to the study of theoretical and applied aspects of human muscle performance. Since isokinetic dynamometry constitutes the major tool in this area, the journal takes a particular interest in exploring the considerable potential of this technology. IES publishes studies associated with the methodology of muscle performance especially with respect to the issues of reproducibility and validity of testing, description of normal and pathological mechanical parameters which are derivable from muscle testing, applications in basic research topics such as motor learning paradigms and electromyography. The journal also publishes studies on applications in clinical settings and technical aspects of the various measurement systems employed in human muscle performance research. The journal welcomes submissions in the form of research papers, reviews, case studies and technical reports from professionals in the fields of sports medicine, orthopaedic and neurological rehabilitation and exercise physiology.