Resveratrol and prednisolone loaded into human serum albumin nanoparticles for the alleviation of rheumatoid arthritis symptoms: an in vitro and in vivo study

IF 1.3 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Science-Poland Pub Date : 2024-06-28 DOI:10.2478/msp-2024-0005

Yongcai Song, Yujia Su, Shaik Althaf Hussain, Cuiping Tang

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Abstract

Rheumatoid arthritis is a chronic autoimmune-disease-causing inflammation, joint pain, and joint destruction, severely affecting the quality of life of millions worldwide. In the current research, a nanocarrier system was developed for the delivery of resveratrol and prednisolone to treat rheumatoid arthritis. The drug delivery system was characterized in vitro using scanning electron microscopy and various cell culture studies. Finally, the alleviative symptoms of the developed treatment strategy were investigated in a rat model of rheumatoid arthritis. In vitro studies showed that the carrier system released the drugs in a sustained manner and possessed strong immunomodulatory functions. Nanocarriers loaded with prednisolone, resveratrol, and drug-free carriers had 396.88 ± 76.41 nm, 392.49 ± 97.31 nm, and 338.02 ± 77.75 nm of mean particle size, respectively. In vivo studies revealed that local injection of the carrier system could alleviate the degenerative effects of rheumatoid arthritis. ELISA assays showed that the co-injection of resveratrol and prednisolone-loaded albumin nanoparticles could significantly modulate inflammatory responses. The developed treatment modality may potentially be used to treat rheumatoid arthritis.

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将白藜芦醇和泼尼松龙载入人血清白蛋白纳米颗粒以缓解类风湿性关节炎症状：一项体外和体内研究

类风湿性关节炎是一种慢性自身免疫性疾病，会引起炎症、关节疼痛和关节破坏，严重影响全球数百万人的生活质量。目前的研究开发了一种纳米载体系统，用于输送白藜芦醇和泼尼松龙治疗类风湿性关节炎。利用扫描电子显微镜和各种细胞培养研究对该给药系统进行了体外表征。最后，在类风湿性关节炎大鼠模型中研究了所开发治疗策略的缓解症状效果。体外研究表明，载体系统能持续释放药物，并具有很强的免疫调节功能。负载泼尼松龙、白藜芦醇和无药载体的纳米载体的平均粒径分别为 396.88 ± 76.41 nm、392.49 ± 97.31 nm 和 338.02 ± 77.75 nm。体内研究表明，局部注射该载体系统可减轻类风湿性关节炎的退行性影响。酶联免疫吸附试验表明，同时注射白藜芦醇和泼尼松龙负载的白蛋白纳米颗粒可显著调节炎症反应。所开发的治疗模式可用于治疗类风湿性关节炎。

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来源期刊

Materials Science-Poland MATERIALS SCIENCE, MULTIDISCIPLINARY-

自引率

18.20%

发文量

期刊介绍： Material Sciences-Poland is an interdisciplinary journal devoted to experimental research into results on the relationships between structure, processing, properties, technology, and uses of materials. Original research articles and review can be only submitted.