Activation of fetal-like molecular programs during regeneration in the intestine and beyond.

Sara Viragova, Dong Li, Ophir D Klein
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引用次数: 0

Abstract

Tissue regeneration after damage is generally thought to involve the mobilization of adult stem cells that divide and differentiate into progressively specialized progeny. However, recent studies indicate that tissue regeneration can be accompanied by reversion to a fetal-like state. During this process, cells at the injury site reactivate programs that operate during fetal development but are typically absent in adult homeostasis. Here, we summarize our current understanding of the molecular signals and epigenetic mediators that orchestrate "fetal-like reversion" during intestinal regeneration. We also explore evidence for this phenomenon in other organs and species and highlight open questions that merit future examination.

在肠道再生及其他过程中激活胎儿样分子程序
损伤后的组织再生通常被认为涉及成体干细胞的动员,这些干细胞分裂并分化成逐渐特化的后代。然而,最近的研究表明,组织再生可能伴随着恢复到类似胎儿的状态。在这一过程中,损伤部位的细胞会重新激活在胎儿发育过程中运行、但在成人稳态中通常不存在的程序。在此,我们总结了目前我们对在肠道再生过程中协调 "类胎儿还原 "的分子信号和表观遗传介质的理解。我们还探讨了这一现象在其他器官和物种中的证据,并强调了值得未来研究的开放性问题。
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