OCTA: Essential or Gimmick?

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-09-01 Epub Date: 2024-07-06 DOI:10.1007/s40123-024-00985-0

Siddharth Gandhi, Niveditha Pattathil, Netan Choudhry

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Abstract

This commentary article delves into the transformative role of optical coherence tomography angiography (OCTA) in diagnosing and managing a wide array of eye conditions, including diabetic retinopathy, age-related macular degeneration, retinal vein occlusions, and white dot syndromes. Developed in 2005, OCTA has emerged as a non-invasive, high-resolution imaging technique that offers advantages over traditional fluorescein angiography (FA), providing quicker and safer monitoring of ocular conditions with similar diagnostic accuracy. In diabetic retinopathy, OCTA has been instrumental in early identification of retinal changes, offering quantifiable metrics including perfused capillary density (PCD) for assessing vascular alterations. For age-related macular degeneration (AMD), OCTA has deepened our understanding of non-exudative neovascular AMD, allowing for more effective monitoring and potential earlier initiation of treatment. In cases of retinal vein occlusions, OCTA can reveal specific microvascular features and allow for depth-resolved measurements of the foveal avascular zone, providing significant prognostic implications. OCTA has also been invaluable in studying rare white dot syndromes, enabling nuanced differentiation between conditions that often present similarly. Emerging research also suggests that OCTA can have potential utility in neurodegenerative diseases like Alzheimer's, where retinal vascular patterns could offer diagnostic insights. While OCTA is revolutionizing ophthalmic care, further clinical trials and standardization are needed for its broader adoption into clinical practice.

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OCTA：必要还是噱头？

这篇评论文章深入探讨了光学相干断层血管造影术（OCTA）在诊断和管理糖尿病视网膜病变、老年性黄斑变性、视网膜静脉闭塞和白点综合征等多种眼部疾病方面的变革性作用。OCTA 开发于 2005 年，是一种无创、高分辨率成像技术，与传统的荧光素血管造影术（FA）相比，它具有更多优势，能更快速、更安全地监测眼部病变，诊断准确率也与之相当。在糖尿病视网膜病变方面，OCTA 在早期识别视网膜病变方面发挥了重要作用，它提供了可量化的指标，包括用于评估血管病变的灌注毛细血管密度（PCD）。对于老年性黄斑变性（AMD），OCTA加深了我们对非渗出性新生血管性AMD的了解，从而可以进行更有效的监测，并有可能更早地开始治疗。在视网膜静脉闭塞的病例中，OCTA 可以显示特定的微血管特征，并能对眼窝无血管区进行深度分辨测量，从而对预后产生重要影响。OCTA 在研究罕见的白点综合征方面也非常有价值，它能对通常表现相似的病症进行细致的区分。新近的研究还表明，OCTA 在阿尔茨海默氏症等神经退行性疾病中也有潜在的应用价值，视网膜血管模式可为诊断提供洞察力。虽然 OCTA 正在为眼科护理带来革命性的变化，但要将其更广泛地应用于临床实践，还需要进一步的临床试验和标准化工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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