Divergent Roles of APOAI and APOM in the Identification of Alcohol Use Disorder and Their Association With Inflammation and Cognitive Decline: A Pilot Study.

IF 4.5 2区 医学 Q1 CLINICAL NEUROLOGY
Berta Escudero, Leticia López-Valencia, Francisco Arias Horcajadas, Laura Orio
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引用次数: 0

Abstract

Background: Alcohol use disorder (AUD) courses with inflammation and cognitive decline. Apolipoproteins have emerged as novel target compounds related to inflammatory processes and cognition.

Methods: A cross-sectional study was performed on abstinent AUD patients with at least 1 month of abstinence (n  = 33; 72.7% men) and healthy controls (n  = 34; 47.1% men). A battery of plasma apolipoproteins (APOAI, APOAII, APOB, APOCII, APOE, APOJ, and APOM), plasma inflammatory markers (LPS, LBP), and their influence on cognition and presence of the disorder were investigated.

Results: Higher levels of plasma APOAI, APOB, APOE, and APOJ, as well as the proinflammatory LPS, were observed in the AUD group, irrespective of sex, whereas APOM levels were lower vs controls. Hierarchical logistic regression analyses, adjusting for covariates (age, sex, education), associated APOM with the absence of cognitive impairment in AUD and identified APOAI and APOM as strong predictors of the presence or absence of the disorder, respectively. APOAI and APOM did not correlate with alcohol abuse variables or liver status markers, but they showed an opposite profile in their associations with LPS (positive for APOAI; negative for APOM) and cognition (negative for APOAI; positive for APOM) in the entire sample.

Conclusions: The HDL constituents APOAI and APOM were differentially regulated in the plasma of AUD patients compared with controls, playing divergent roles in the disorder identification and associations with inflammation and cognitive decline.

APOAI和APOM在识别酒精使用障碍中的不同作用及其与炎症和认知衰退的关系:一项试点研究。
背景:酒精使用障碍(AUD)会导致炎症和认知能力下降。载脂蛋白已成为与炎症过程和认知能力相关的新型目标化合物:对至少戒酒一个月的戒酒 AUD 患者(33 人;72.7% 为男性)和健康对照组(34 人;47.1% 为男性)进行了横断面研究。研究调查了一系列血浆脂蛋白(APOAI、APOAII、APOB、APOCII、APOE、APOJ 和 APOM)、血浆炎症标志物(LPS、LBP)及其对认知能力和是否存在障碍的影响:不分性别,AUD 组的血浆 APOAI、APOB、APOE 和 APOJ 以及促炎性 LPS 水平较高,而 APOM 水平则低于对照组。在调整协变量(年龄、性别、教育程度)后进行的层次逻辑回归分析显示,APOM 与 AUD 是否存在认知障碍有关,并确定 APOAI 和 APOM 分别是预测是否存在认知障碍的有力指标。APOAI和APOM与酗酒变量或肝脏状态标志物没有相关性,但在整个样本中,它们与LPS(APOAI为阳性;APOM为阴性)和认知(APOAI为阴性;APOM为阳性)的关系却显示出相反的特征:结论:与对照组相比,高密度脂蛋白成分 APOAI 和 APOM 在 AUD 受试者的血浆中受到不同程度的调节,在疾病识别以及与炎症和认知能力下降的关联中发挥着不同的作用。
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来源期刊
CiteScore
8.40
自引率
2.10%
发文量
230
审稿时长
4-8 weeks
期刊介绍: The central focus of the journal is on research that advances understanding of existing and new neuropsychopharmacological agents including their mode of action and clinical application or provides insights into the biological basis of psychiatric disorders and thereby advances their pharmacological treatment. Such research may derive from the full spectrum of biological and psychological fields of inquiry encompassing classical and novel techniques in neuropsychopharmacology as well as strategies such as neuroimaging, genetics, psychoneuroendocrinology and neuropsychology.
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