Unraveling the intricacies of cold-inducible RNA-binding protein: A comprehensive review

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
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Abstract

Cold-inducible RNA-binding protein (CIRP) is a versatile RNA-binding protein, pivotal in modulating cellular responses to diverse stress stimuli including cold shock, ultraviolet radiation, hypoxia, and infections, with a principal emphasis on cold stress. The temperature range of 32–34 °C is most suitable for CIRP expression. The human CIRP is an 18–21 kDa polypeptide containing 172 amino acids coded by a gene located on chromosome 19p13.3. CIRP has an RNA-recognition motif (RRM) and an arginine-rich motif (RGG), both of which have roles in coordinating numerous cellular activities. CIRP itself also undergoes conformational changes in response to diverse environmental stress. Transcription factors such as hypoxia-inducible factor 1 alpha and nuclear factor-kappa B have been implicated in coordinating CIRP transcription in response to specific stimuli. The potential of CIRP to relocate from the nucleus to the cytoplasm upon exposure to different stimuli enhances its varied functional roles across different cellular compartments. The different functions include decreasing nutritional demand, apoptosis suppression, modulation of translation, and preservation of cytoskeletal integrity at lower temperatures. This review explores the diverse functions and regulatory mechanisms of CIRP, shedding light on its involvement in various cellular processes and its implications for human health and disease.

揭示冷诱导 RNA 结合蛋白的复杂性:全面回顾。
冷诱导 RNA 结合蛋白(CIRP)是一种多功能的 RNA 结合蛋白,在调节细胞对冷休克、紫外线辐射、缺氧和感染等各种应激刺激的反应中起着关键作用,主要作用于冷应激。32-34°C 的温度范围最适合 CIRP 的表达。人类 CIRP 是一种 18-21kDa 的多肽,含有 172 个氨基酸,由位于染色体 19p13.3 上的基因编码。CIRP 有一个 RNA 识别基序(RRM)和一个富含精氨酸的基序(RGG),这两个基序在协调多种细胞活动中发挥作用。CIRP 本身也会在各种环境压力下发生构象变化。缺氧诱导因子 1 alpha(HIF-1α)和核因子-kappa B(NF-κB)等转录因子与协调 CIRP 在特定刺激下的转录有关。在受到不同刺激时,CIRP 有可能从细胞核转移到细胞质,这增强了它在不同细胞区的不同功能作用。不同的功能包括降低营养需求、抑制细胞凋亡、调节翻译以及在较低温度下保持细胞骨架的完整性。这篇综述探讨了 CIRP 的各种功能和调控机制,揭示了它在各种细胞过程中的参与及其对人类健康和疾病的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell Stress & Chaperones
Cell Stress & Chaperones 生物-细胞生物学
CiteScore
7.60
自引率
2.60%
发文量
59
审稿时长
6-12 weeks
期刊介绍: Cell Stress and Chaperones is an integrative journal that bridges the gap between laboratory model systems and natural populations. The journal captures the eclectic spirit of the cellular stress response field in a single, concentrated source of current information. Major emphasis is placed on the effects of climate change on individual species in the natural environment and their capacity to adapt. This emphasis expands our focus on stress biology and medicine by linking climate change effects to research on cellular stress responses of animals, micro-organisms and plants.
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