Advancements in inhibitors of crucial enzymes in the cysteine biosynthetic pathway: Serine acetyltransferase and O-acetylserine sulfhydrylase

IF 3.2 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yinhui Qin, Yuetai Teng, Yan Yang, Zhenkun Mao, Shengyu Zhao, Na Zhang, Xu Li, Weihong Niu
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Abstract

Infectious diseases have been jeopardized problem that threaten public health over a long period of time. The growing prevalence of drug-resistant pathogens and infectious cases have led to a decrease in the number of effective antibiotics, which highlights the urgent need for the development of new antibacterial agents. Serine acetyltransferase (SAT), also known as CysE in certain bacterial species, and O-acetylserine sulfhydrylase (OASS), also known as CysK in select bacteria, are indispensable enzymes within the cysteine biosynthesis pathway of various pathogenic microorganisms. These enzymes play a crucial role in the survival of these pathogens, making SAT and OASS promising targets for the development of novel anti-infective agents. In this comprehensive review, we present an introduction to the structure and function of SAT and OASS, along with an overview of existing inhibitors for SAT and OASS as potential antibacterial agents. Our primary focus is on elucidating the inhibitory activities, structure–activity relationships, and mechanisms of action of these inhibitors. Through this exploration, we aim to provide insights into promising strategies and prospects in the development of antibacterial agents that target these essential enzymes.

Abstract Image

半胱氨酸生物合成途径中关键酶抑制剂的研究进展:丝氨酸乙酰转移酶和 O-乙酰丝氨酸巯基酶。
长期以来,传染病一直是威胁公众健康的棘手问题。耐药性病原体和传染病病例的日益增多导致有效抗生素的数量减少,这突出表明迫切需要开发新的抗菌剂。丝氨酸乙酰转移酶(SAT)(在某些细菌物种中也称为 CysE)和 O-乙酰丝氨酸巯基酶(OASS)(在某些细菌中也称为 CysK)是各种病原微生物半胱氨酸生物合成途径中不可或缺的酶。这些酶对这些病原体的生存起着至关重要的作用,因此 SAT 和 OASS 是开发新型抗感染药物的理想靶标。在这篇综述中,我们介绍了 SAT 和 OASS 的结构和功能,并概述了作为潜在抗菌剂的现有 SAT 和 OASS 抑制剂。我们的主要重点是阐明这些抑制剂的抑制活性、结构-活性关系和作用机制。通过这一探索,我们旨在为针对这些重要酶的抗菌剂的开发提供有前途的策略和前景。
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来源期刊
Chemical Biology & Drug Design
Chemical Biology & Drug Design 医学-生化与分子生物学
CiteScore
5.10
自引率
3.30%
发文量
164
审稿时长
4.4 months
期刊介绍: Chemical Biology & Drug Design is a peer-reviewed scientific journal that is dedicated to the advancement of innovative science, technology and medicine with a focus on the multidisciplinary fields of chemical biology and drug design. It is the aim of Chemical Biology & Drug Design to capture significant research and drug discovery that highlights new concepts, insight and new findings within the scope of chemical biology and drug design.
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