Ex-situ machine perfusion in clinical liver transplantation: Current practices and future directions.

IF 4.7 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Liver Transplantation Pub Date : 2025-04-01 Epub Date: 2024-07-08 DOI:10.1097/LVT.0000000000000428

Michelle C Nguyen, Xingjie Li, Natalia Linares, Caroline Jadlowiec, Adyr Moss, Kunam S Reddy, Amit K Mathur

引用次数: 0

Abstract

Ex-situ machine perfusion of the liver has surmounted traditional limitations associated with static cold storage in the context of organ preservation. This innovative technology has changed the landscape of liver transplantation by mitigating ischemia perfusion injury, offering a platform for continuous assessment of organ quality, and providing an avenue for optimizing the use of traditionally marginal allografts. This review summarizes the contemporary clinical applications of machine perfusion devices and discusses potential future strategies for real-time viability assessment, therapeutic interventions, and modulation of organ function after recovery.

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临床肝移植中的原位机器灌注：当前实践与未来方向。

在器官保存方面，肝脏原位机器灌注克服了与静态冷藏相关的传统限制。这项创新技术减轻了缺血灌注损伤，提供了一个持续评估器官质量的平台，并为优化使用传统边缘异体移植物提供了途径，从而改变了肝移植的格局。本综述总结了机器灌注设备的当代临床应用，并讨论了实时活力评估、治疗干预和恢复后器官功能调节的潜在未来策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Liver Transplantation 医学-外科

CiteScore

7.40

自引率

6.50%

发文量

254

审稿时长

3-8 weeks

期刊介绍： Since the first application of liver transplantation in a clinical situation was reported more than twenty years ago, there has been a great deal of growth in this field and more is anticipated. As an official publication of the AASLD, Liver Transplantation delivers current, peer-reviewed articles on liver transplantation, liver surgery, and chronic liver disease — the information necessary to keep abreast of this evolving specialty.