Protein degradation by a component of the chaperonin-linked protease ClpP

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Fumihiro Ishikawa, Michio Homma, Genzoh Tanabe, Takayuki Uchihashi
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引用次数: 0

Abstract

In cells, proteins are synthesized, function, and degraded (dead). Protein synthesis (spring) is important for the life of proteins. However, how proteins die is equally important for organisms. Proteases are secreted from cells and used as nutrients to break down external proteins. Proteases degrade unwanted and harmful cellular proteins. In eukaryotes, a large enzyme complex called the proteasome is primarily responsible for cellular protein degradation. Prokaryotes, such as bacteria, have similar protein degradation systems. In this review, we describe the structure and function of the ClpXP complex in the degradation system, which is an ATP-dependent protease in bacterial cells, with a particular focus on ClpP.

Abstract Image

伴侣蛋白连接蛋白酶 ClpP 的一种成分对蛋白质的降解作用。
在细胞中,蛋白质进行合成、发挥功能和降解(死亡)。蛋白质的合成(春季)对蛋白质的生命非常重要。然而,蛋白质如何死亡对生物体同样重要。蛋白酶是从细胞中分泌出来的,用作分解外部蛋白质的营养物质。蛋白酶可以降解不需要的和有害的细胞蛋白质。在真核生物中,一种名为蛋白酶体的大型酶复合物主要负责降解细胞蛋白质。细菌等原核生物也有类似的蛋白质降解系统。在这篇综述中,我们描述了降解系统中的 ClpXP 复合物的结构和功能,它是细菌细胞中一种依赖 ATP 的蛋白酶,尤其侧重于 ClpP。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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