"Couple's Immunotherapy": Is CXCL13 at the Heart of the Prescription?

IF 8.1 1区医学 Q1 IMMUNOLOGY

Cancer immunology research Pub Date : 2024-08-01 DOI:10.1158/2326-6066.CIR-24-0481

Eduardo Cruz-Hinojoza, Ingunn M Stromnes

引用次数: 0

Abstract

Sex differences in cancer survivorship and response to immunotherapy have been observed, with males generally displaying better outcomes to immune checkpoint blockade compared with females. In this article, by interrogating public lung cancer sequencing datasets, Brennan and colleagues uncover a chemokine axis that may contribute to disparate immunotherapy outcomes between the sexes. See related article by Brennan et al., p. 956 (3).

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"夫妻免疫疗法"：CXCL13 是处方的核心吗？

在癌症存活率和对免疫疗法的反应方面，人们观察到了性别差异，与女性相比，男性对免疫检查点阻断的疗效通常更好。在这篇文章中，Brennan及其同事通过研究公开的肺癌测序数据集，发现了一种趋化因子轴，它可能是造成两性免疫疗法结果差异的原因。参见 Brennan 等人的相关文章，第 XXX (3) 页。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer immunology research ONCOLOGY-IMMUNOLOGY

CiteScore

15.60

自引率

1.00%

发文量

260

期刊介绍： Cancer Immunology Research publishes exceptional original articles showcasing significant breakthroughs across the spectrum of cancer immunology. From fundamental inquiries into host-tumor interactions to developmental therapeutics, early translational studies, and comprehensive analyses of late-stage clinical trials, the journal provides a comprehensive view of the discipline. In addition to original research, the journal features reviews and opinion pieces of broad significance, fostering cross-disciplinary collaboration within the cancer research community. Serving as a premier resource for immunology knowledge in cancer research, the journal drives deeper insights into the host-tumor relationship, potent cancer treatments, and enhanced clinical outcomes. Key areas of interest include endogenous antitumor immunity, tumor-promoting inflammation, cancer antigens, vaccines, antibodies, cellular therapy, cytokines, immune regulation, immune suppression, immunomodulatory effects of cancer treatment, emerging technologies, and insightful clinical investigations with immunological implications.