The therapeutic potential of Melissa officinalis L. hydroalcoholic extract and rosmarinic acid in a rat asthmatic model: A study on anti-inflammatory and antioxidant effects.

IF 1.9 Q3 CHEMISTRY, MEDICINAL
Vahideh Abbasnia, Delaram Eslimi Esfahani, Mohammad Reza Khazdair, Shahrbanoo Oryan, Mohsen Foadoddini
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引用次数: 0

Abstract

Objective: The article studies how Melissa officinalis L. extract and rosmarinic acid (RA) affect lung inflammation, pathology, and oxidative stress in rats with ovalbumin-induced asthma.

Materials and methods: Asthma was induced in rats using ovalbumin injection and inhalation. The study assessed lung inflammation, pathological changes, and oxidative stress in control, untreated asthmatic rats and three treatment groups. These groups received M. officinalis extract (50, 100, 200 mg/kg), RA (0.5, 1, 2 mg/kg), or dexamethasone (Dex) 1 mg/kg.

Results: In the sensitized group, white blood cell counts, malondialdehyde, and nitrite levels increased significantly, while thiol levels and the activity of superoxide dismutase and catalase decreased (p<0.001). However, all treatment groups with the extract, RA, and Dex showed a significant reduction in total white blood cells, eosinophils, monocytes, malondialdehyde, and nitrite levels compared to the asthma group (p<0.001 in all groups). Thiol levels and catalase and superoxide dismutase activity were significantly higher in all treated groups with RA and high extract doses (p<0.001). Lung pathological changes were also significantly less severe in the treated groups with dexamethasone, plant extract, and RA compared to the asthma group (p<0.05 to p<0.001).

Conclusion: This study showed that M. officinalis and RA have antioxidant and anti-inflammatory effects in an animal asthma model, suggesting their potential for treating asthma symptoms.

Melissa officinalis L. 水醇提取物和迷迭香酸在大鼠哮喘模型中的治疗潜力:抗炎和抗氧化作用研究。
目的:文章研究了香蜂草提取物和迷迭香酸(RA)如何影响卵清蛋白诱导的哮喘大鼠的肺部炎症、病理和氧化应激:采用卵清蛋白注射和吸入法诱导大鼠哮喘。研究评估了对照组、未治疗的哮喘大鼠和三个治疗组的肺部炎症、病理变化和氧化应激。这些组分别接受了欧当归提取物(50、100、200 毫克/千克)、RA(0.5、1、2 毫克/千克)或地塞米松(Dex)1 毫克/千克的治疗:结果:在致敏组中,白细胞计数、丙二醛和亚硝酸盐水平显著升高,而硫醇水平以及超氧化物歧化酶和过氧化氢酶的活性降低(pConclusion):本研究表明,M. officinalis 和 RA 在动物哮喘模型中具有抗氧化和抗炎作用,这表明它们具有治疗哮喘症状的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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