Longitudinal Analysis of Renal Function Changes in Elderly Populations: Health Status Evaluation and Risk Factor Assessment

IF 3.6 3区医学

Clinical Interventions in Aging Pub Date : 2024-07-03 DOI:10.2147/cia.s450388

Lengnan Xu, Chen Yu, Aiqun Chen, Chuanbao Li, Yonghui Mao

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引用次数: 0

Abstract

Background: This study aims to investigate GFR decline in elderly subjects with varying physical conditions and analyze key risk factors impacting renal function changes.
Methods: We obtained data from patients between 2017 and 2019, and matched healthy elderly subjects based on gender and age. Data collected for all subjects included annual measurements of fast blood glucose (GLU), glycated hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL-c), blood albumin (ALB), blood uric acid (UA), urine protein (UP), and systolic blood pressure (SBP). Additionally, information on coexisting diseases was gathered. The Full Age Spectrum (FAS) equation was used to calculate eGFR.
Results: A total of 162 patients with complete 3-year renal dynamic imaging were included, including 84 patients in the kidney disease group (K group) and 78 patients in the non-kidney disease group (NK group). Ninety individuals were selected as the healthy group (H group). The annual decline rate in the K group was the fastest, which exceeded 5mL/min/1.73m² (P < 0.05). Group (K group: β=− 40.31, P< 0.001; NK group: β=− 26.96, P< 0.001), ALB (β=− 0.38, P=0.038) and HbA1c (β=1.36, P=0.029) had a significant negative impact on the eGFR changes. For participants who had negative proteinuria: K group had the most significant annual eGFR decline.
Conclusion: The presence of kidney disease, along with proteinuria nor not, can lead to a marked acceleration in kidney function decline in elderly. We categorize elderly individuals with an annual eGFR decline of more than 5 mL/min/1.73m² as the “kidney accelerated aging” population.

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老年人群肾功能变化的纵向分析：健康状况评估和风险因素评估

背景：本研究旨在调查不同身体状况老年人的 GFR 下降情况，并分析影响肾功能变化的主要风险因素：本研究旨在调查不同身体状况的老年受试者的 GFR 下降情况，并分析影响肾功能变化的主要风险因素：我们获取了 2017 年至 2019 年期间患者的数据，并根据性别和年龄匹配了健康老年受试者。对所有受试者收集的数据包括每年测量的快速血糖（GLU）、糖化血红蛋白（HbA1c）、低密度脂蛋白胆固醇（LDL-c）、血白蛋白（ALB）、血尿酸（UA）、尿蛋白（UP）和收缩压（SBP）。此外，还收集了并存疾病的信息。采用全年龄谱（FAS）方程计算 eGFR：共纳入了 162 名 3 年肾脏动态成像完整的患者，包括 84 名肾脏疾病组（K 组）患者和 78 名非肾脏疾病组（NK 组）患者。90人被选为健康组（H组）。K 组的年下降率最快，超过了 5 毫升/分钟/1.73 平方米（P < 0.05）。组别（K 组：β=- 40.31，P< 0.001；NK 组：β=- 26.96，P< 0.001）、ALB（β=- 0.38，P=0.038）和 HbA1c（β=1.36，P=0.029）对 eGFR 变化有显著的负面影响。对于蛋白尿呈阴性的参与者：K 组的 eGFR 年下降幅度最大：结论：肾脏疾病、蛋白尿或无蛋白尿都会导致老年人肾功能明显加速衰退。我们将每年 eGFR 下降超过 5 毫升/分钟/1.73 平方米的老年人归类为 "肾脏加速衰老 "人群。

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.20

自引率

2.80%

发文量

193

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.