Chemically Peptide Synthesis and Role of Arginine and Lysine in the Antimicrobial and Antiviral Activity of Synthetic Peptides: A Comprehensive Review

IF 1.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Peptide Science Pub Date : 2024-06-26 DOI:10.1002/pep2.24368

Selin Zeynep Sunar, Tayfun Acar, Fikrettin Sahin

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引用次数: 0

Abstract

This review examines the potential applications of peptides in biotechnology, medicine, and pharmacy, while highlighting the important antibacterial and antiviral properties of peptides. Peptides and chemical peptide synthesis have become a field of study that is gaining great momentum today. Some of the main reasons for this are high specificity, biodegradability and versatility of peptides. Peptides also have some specific properties that make them attractive for pharmaceutical development. As a case study, it can be used to create peptides that can be used to replace or fix damaged proteins in the body by mimicking the action of naturally occurring proteins. Delivering drugs or other therapeutic agents to specific cells or tissues is another method that can help increase the effectiveness of treatment and reduce unwanted effects. Various types of antimicrobial peptides (AMPs), such as defensins and cathelicidins, and their anti‐infective properties are also discussed. Finally, peptides (melittin, lactoferricin, etc.) can be used to trigger an immune response against certain infections, such as COVID‐19 and Zika virus, by acting as vaccines. In our study, a comprehensive review was made on antiviral and AMPs, and especially peptides containing arginine and lysine were mentioned. The properties of these peptides, examples of these peptides and their developments in the pharmaceutical field are emphasized.

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化学多肽合成以及精氨酸和赖氨酸在合成多肽抗菌和抗病毒活性中的作用：全面综述

这篇综述探讨了多肽在生物技术、医学和药学中的潜在应用，同时强调了多肽重要的抗菌和抗病毒特性。肽和肽化学合成已成为当今势头强劲的研究领域。其中一些主要原因是肽具有高特异性、生物可降解性和多功能性。肽还具有一些特殊性质，使其在药物开发方面具有吸引力。举例来说，多肽可用于模仿天然蛋白质的作用，从而替代或修复体内受损的蛋白质。向特定细胞或组织输送药物或其他治疗剂是另一种方法，有助于提高治疗效果并减少不必要的影响。此外，还讨论了各种类型的抗菌肽（AMPs），如防御素和白细胞介素，以及它们的抗感染特性。最后，肽（美利肽、乳铁蛋白等）可用作疫苗，引发对某些感染（如 COVID-19 和寨卡病毒）的免疫反应。在我们的研究中，我们全面回顾了抗病毒和 AMPs，尤其提到了含有精氨酸和赖氨酸的肽。我们强调了这些肽的特性、实例及其在制药领域的发展。

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来源期刊

Peptide Science Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

5.20

自引率

4.20%

发文量

期刊介绍： The aim of Peptide Science is to publish significant original research papers and up-to-date reviews covering the entire field of peptide research. Peptide Science provides a forum for papers exploring all aspects of peptide synthesis, materials, structure and bioactivity, including the use of peptides in exploring protein functions and protein-protein interactions. By incorporating both experimental and theoretical studies across the whole spectrum of peptide science, the journal serves the interdisciplinary biochemical, biomaterials, biophysical and biomedical research communities. Peptide Science is the official journal of the American Peptide Society.