Benzothiazole-Directed Enantioselective Borylation of Secondary Benzylic C–H Bonds Using Iridium Catalysis

Synthesis Pub Date : 2024-06-24 DOI:10.1055/a-2335-8677
Liang-Jun Xie, Lili Chen, Senmiao Xu
{"title":"Benzothiazole-Directed Enantioselective Borylation of Secondary Benzylic C–H Bonds Using Iridium Catalysis","authors":"Liang-Jun Xie, Lili Chen, Senmiao Xu","doi":"10.1055/a-2335-8677","DOIUrl":null,"url":null,"abstract":"<p>Reported here is the iridium-catalyzed regio- and enantio­selective secondary benzylic C–H borylation using benzothiazole as the directing group. Various monosubstituted 2-arylalkylbenzo[<i>d</i>]thiazole were well-tolerated, affording the corresponding products in moderate to good yields with good enantioselectivity. The C–B bond in one boryl­ated product could undergo stereospecific transformations to form a series of C–C and C–heteroatom bonds.</p> ","PeriodicalId":501298,"journal":{"name":"Synthesis","volume":"66 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthesis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/a-2335-8677","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Reported here is the iridium-catalyzed regio- and enantio­selective secondary benzylic C–H borylation using benzothiazole as the directing group. Various monosubstituted 2-arylalkylbenzo[d]thiazole were well-tolerated, affording the corresponding products in moderate to good yields with good enantioselectivity. The C–B bond in one boryl­ated product could undergo stereospecific transformations to form a series of C–C and C–heteroatom bonds.

Abstract Image

利用铱催化实现苯并噻唑引导的仲苄基 C-H 键对映选择性硼酰化反应
这里报告的是以苯并噻唑为指导基团,在铱催化下进行的区域和对映选择性仲苄基 C-H 硼酰化反应。各种单取代的 2-芳烷基苯并[d]噻唑均具有良好的耐受性,能以中等至良好的产率和良好的对映选择性得到相应的产物。一种硼烷基化产物中的 C-B 键可发生立体特异性转化,形成一系列 C-C 键和 C-杂原子键。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信