Green synthesis of novel cyclopentapyridines: One-pot multicomponent reactions of vinilydene Meldrum's acid

Abstract

This study focused on the investigation of synthesizing new derivatives of cyclopentapyridines with high yields employing multicomponent reaction that involved vinilydene Meldrum's acid, ethyl 2-amino-4-dioxo-4-arylbutanoates, hydrazonoyl chlorides, and activated acetylenic compounds. The reaction was conducted in water at room temperature, resulting in the synthesis of new compounds. Also, the reaction of synthesized cyclopentapyridines with dimethyl acetylenedicarboxylate was performed in water at room temperature which produced other cyclopentapyridine derivatives by elimination of N₂. The advantages of this technology encompass rapid response times, high product yields, and facile product separation via uncomplicated procedures.