Efficient Inactivation of Influenza Virus Through Adsorption of Nanoceria and its Oxidative Power

IF 1.4 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Chemistry Letters Pub Date : 2024-06-21 DOI:10.1093/chemle/upae124

Shota Sekiguchi, Eisuke Umezawa, Hiroko Ito Yamanaka, Kan Fujino, Takahiro Motoshiromizu, Miho Kawanishi Ouchi, Shunsuke Murai, Tomohide Masuda, Masateru Ito, Hitoshi Nobumasa, Satoshi Taharaguchi

引用次数: 0

Abstract

This study investigated the stabilizer's impact on nanoceria's antiviral activity. The positively charged nanoceria dispersion showed potent activity against the influenza virus, reducing the viral titer by over 4.0 log10 pfu/mL within 1 h, surpassing EN14476 criteria. It also inactivated the virus within 15 s, decreasing the infection titer by 2.2 log10 pfu/mL, and maintained efficacy even under bovine serum albumin loading.

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通过吸附纳米铈及其氧化能力高效灭活流感病毒

本研究调查了稳定剂对纳米铈抗病毒活性的影响。带正电荷的纳米微粒分散体对流感病毒具有很强的活性，在 1 小时内将病毒滴度降低了 4.0 log10 pfu/mL 以上，超过了 EN14476 标准。它还能在 15 秒内灭活病毒，使感染滴度降低 2.2 log10 pfu/mL，即使在牛血清白蛋白负载的情况下也能保持功效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry Letters 化学-化学综合

CiteScore

3.00

自引率

6.20%

发文量

260

审稿时长

1.2 months

期刊介绍： Chemistry Letters covers the following topics: -Organic Chemistry- Physical Chemistry- Inorganic Chemistry- Analytical Chemistry- Materials Chemistry- Polymer Chemistry- Supramolecular Chemistry- Organometallic Chemistry- Coordination Chemistry- Biomolecular Chemistry- Natural Products and Medicinal Chemistry- Electrochemistry