3-Spiroandrostene-substituted 1,3,4-thiadiazolines

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-28 DOI:10.1007/s10593-024-03317-z

Alexander V. Komkov, Leonid G. Menchikov, Andrey S. Dmitrenok, Natalya G. Kolotyrkina, Igor V. Zavarzin

引用次数: 0

Abstract

A method for the synthesis of 1,3,4-thiadiazoline spiro steroids via ring A by the reaction of steroid 3-ketones with oxamic acid thiohydrazides was developed. It was shown that if a keto group was present both in ring A and in ring D of the precursor steroid, the reaction occurred only at the keto group of ring A. A number of new steroidal 3-spiroandrostene-substituted 1,3,4-thiadiazolines were obtained, which could be easily acetylated at the thiadiazole NH group.

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3-螺蒽取代的 1,3,4-噻二唑啉类化合物

通过类固醇 3-酮与氨基甲酸硫酰肼的反应，开发了一种通过环 A 合成 1,3,4-噻二唑啉螺类固醇的方法。结果表明，如果前体类固醇的环 A 和环 D 中都有酮基，则反应只发生在环 A 的酮基上。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.