Regulating Temporal Neural Coding via Fast and Slow Synaptic Dynamics

IF 5 3区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE
Yuanhong Tang;Lingling An;Xingyu Zhang;Huiling Huang;Zhaofei Yu
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引用次数: 0

Abstract

The NMDA receptor (NMDAR), as a ubiquitous type of synapse in neural systems of the brain, presents slow dynamics to modulate neural spiking activity. For the cerebellum, NMDARs have been suggested for contributing complex spikes in Purkinje cells (PCs) as a mechanism for cognitive activity, learning, and memory. Recent experimental studies are debating the role of NMDAR in PC dendritic input, yet it remains unclear how the distribution of NMDARs in PC dendrites can affect their neural spiking coding properties. In this work, a detailed multiple-compartment PC model was used to study how slow-scale NMDARs together with fast-scale AMPA, regulate neural coding. We find that NMDARs act as a band-pass filter, increasing the excitability of PC firing under low-frequency input while reducing it under high frequency. This effect is positively related to the strength of NMDARs. For a response sequence containing a large number of regular and irregular spiking patterns, NMDARs reduce the overall regularity under high-frequency input while increasing the local regularity under low-frequency. Moreover, the inhibitory effect of NMDA receptors during high-frequency stimulation is associated with a reduced conductance of large conductance calcium-activated potassium (BK) channel. Taken together, our results suggest that NMDAR plays an important role in the regulation of neural coding strategies by utilizing its complex dendritic structure.
通过快慢突触动态调节时态神经编码
NMDA受体(NMDAR)作为大脑神经系统中普遍存在的一种突触类型,呈现出缓慢的动态调节神经尖峰活动。对于小脑,NMDARs已被认为在浦肯野细胞(PCs)中作为认知活动、学习和记忆的机制贡献了复杂的峰值。最近的实验研究正在争论NMDAR在PC树突输入中的作用,但仍不清楚NMDAR在PC树突中的分布如何影响其神经脉冲编码特性。在这项工作中,使用了一个详细的多室PC模型来研究慢尺度NMDARs与快速尺度AMPA如何调节神经编码。我们发现NMDARs作为一个带通滤波器,在低频输入下提高PC放电的兴奋性,而在高频输入下降低其兴奋性。这种效应与NMDARs的强度呈正相关。对于包含大量规则和不规则尖峰模式的响应序列,NMDARs在高频输入下降低了整体的规律性,而在低频输入下增加了局部的规律性。此外,NMDA受体在高频刺激下的抑制作用与大电导钙活化钾(BK)通道的电导降低有关。综上所述,我们的研究结果表明,NMDAR通过其复杂的树突结构在神经编码策略的调控中发挥了重要作用。
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来源期刊
CiteScore
7.20
自引率
10.00%
发文量
170
期刊介绍: The IEEE Transactions on Cognitive and Developmental Systems (TCDS) focuses on advances in the study of development and cognition in natural (humans, animals) and artificial (robots, agents) systems. It welcomes contributions from multiple related disciplines including cognitive systems, cognitive robotics, developmental and epigenetic robotics, autonomous and evolutionary robotics, social structures, multi-agent and artificial life systems, computational neuroscience, and developmental psychology. Articles on theoretical, computational, application-oriented, and experimental studies as well as reviews in these areas are considered.
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