Controlling the antibacterial activity of surfactants by hydrotrope addition

IF 1.6 4区 工程技术 Q3 CHEMISTRY, APPLIED
Mina Kurose, Tomohiro Sato, Shigekazu Yano, Yoshimune Nonomura
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Abstract

Hydrotropes are amphiphiles that improve the water solubility of hydrophobic substances. In this study, we systematically evaluated the effects of eight hydrotropes on the antibacterial activity of fatty acids solubilized in a micellar system. The antibacterial activity was evaluated using minimum inhibitory concentration (MIC) as an indicator, and CMC was calculated for interfacial properties based on the measurement of the surface tension and the solubilization behavior of the oil‐soluble dye. The solubilization of lauric acid (12:0 FA) in the micelles of nonionic surfactants increased and decreased the antibacterial activities of the surfactants against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis, respectively. The addition of the hydrotropes decreased the antibacterial activity of the surfactants against both Staphylococci. However, on introducing small amounts of 12:0 FA, the surfactants exhibited selective antibacterial activity against S. aureus. These antibacterial phenomena were observed at concentrations above the critical micelle concentration of the surfactants. These findings suggest that the addition of hydrotropes affects the interfacial properties and antibacterial activity of micellar systems containing antibacterial ingredients.
通过添加氢根离子控制表面活性剂的抗菌活性
羟丙基化合物是一种两亲化合物,可提高疏水性物质的水溶性。在本研究中,我们系统地评估了八种水托品对溶解在胶束体系中的脂肪酸抗菌活性的影响。抗菌活性以最小抑菌浓度(MIC)为指标进行评估,界面特性的 CMC 则根据表面张力的测量和油溶性染料的增溶行为计算得出。月桂酸(12:0 FA)在非离子表面活性剂胶束中的增溶分别提高和降低了表面活性剂对金黄色葡萄球菌和表皮葡萄球菌的抗菌活性。添加氢化托普斯会降低表面活性剂对这两种葡萄球菌的抗菌活性。然而,在引入少量 12:0 FA 后,表面活性剂对金黄色葡萄球菌具有选择性抗菌活性。这些抗菌现象是在表面活性剂的浓度高于临界胶束浓度时观察到的。这些研究结果表明,添加氢化丙烯会影响含有抗菌成分的胶束系统的界面特性和抗菌活性。
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来源期刊
Journal of Surfactants and Detergents
Journal of Surfactants and Detergents 工程技术-工程:化工
CiteScore
3.80
自引率
6.20%
发文量
68
审稿时长
4 months
期刊介绍: Journal of Surfactants and Detergents, a journal of the American Oil Chemists’ Society (AOCS) publishes scientific contributions in the surfactants and detergents area. This includes the basic and applied science of petrochemical and oleochemical surfactants, the development and performance of surfactants in all applications, as well as the development and manufacture of detergent ingredients and their formulation into finished products.
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