Living in urban forests strengthens radical scavenging activity to delay aging: a pilot animal study

IF 2.6 2区农林科学 Q1 FORESTRY

European Journal of Forest Research Pub Date : 2024-06-29 DOI:10.1007/s10342-024-01708-7

Yanling Li, Xiaocong Li

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Abstract

The aging process is influenced by the accumulation of both beneficial and harmful factors in the external environment. While extensive literature has explored the health benefits of short-term forest bathing, the potential for long-term exposure to forests to delay the aging process remains unclear. This study aimed to investigate the impact of prolonged urban forest contact on aging using a murine model. Forty male Specified Pathogen Free degree Kunming mice (6 weeks old, average weight 30.44 ± 0.91 g) were subjected to continuous subcutaneous injection of D-galactose in an urban environment and an urban forest environment to simulate an accelerated aging process lasting six weeks. Results showed that compared to urban environment, mice living in the forest environment exhibited significantly increased levels of serum oxidases CAT, GSH-Px, and SOD, as well as decreased levels of oxidative products H₂O₂ and MDA. These findings suggest that long-term forest living enhances serum Nrf2 expression, downstream oxidase activity, total antioxidant capacity, and resistance to free radicals and oxidative products, thus delaying the aging process. This study offers valuable insights into the potential health benefits of long-term forest living, which may play a role in delaying the aging process in humans.

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生活在城市森林中能增强自由基清除活性，从而延缓衰老：一项试验性动物研究

衰老过程受到外部环境中有益和有害因素积累的影响。虽然已有大量文献探讨了短期森林浴对健康的益处，但长期接触森林对延缓衰老过程的潜力仍不清楚。本研究旨在利用小鼠模型研究长期接触城市森林对衰老的影响。40只雄性无特定病原体昆明小鼠（6周龄，平均体重（30.44 ± 0.91）克）在城市环境和城市森林环境中连续皮下注射D-半乳糖，以模拟持续6周的加速衰老过程。结果表明，与城市环境相比，生活在森林环境中的小鼠血清氧化酶 CAT、GSH-Px 和 SOD 的水平明显升高，氧化产物 H2O2 和 MDA 的水平降低。这些发现表明，长期生活在森林中能增强血清中 Nrf2 的表达、下游氧化酶的活性、总抗氧化能力以及对自由基和氧化产物的抵抗力，从而延缓衰老过程。这项研究为长期森林生活的潜在健康益处提供了宝贵的见解，它可能在延缓人类衰老过程中发挥作用。

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来源期刊

European Journal of Forest Research 农林科学-林学

CiteScore

5.10

自引率

3.60%

发文量

审稿时长

6-16 weeks

期刊介绍： The European Journal of Forest Research focuses on publishing innovative results of empirical or model-oriented studies which contribute to the development of broad principles underlying forest ecosystems, their functions and services. Papers which exclusively report methods, models, techniques or case studies are beyond the scope of the journal, while papers on studies at the molecular or cellular level will be considered where they address the relevance of their results to the understanding of ecosystem structure and function. Papers relating to forest operations and forest engineering will be considered if they are tailored within a forest ecosystem context.