Multiscale Mechanical Modeling of Skeletal Muscle: A Systemic Review of the Literature

IF 1.6 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Aude Loumeaud, Philippe Pouletaut, Sabine F. Bensamoun, Daniel George, Simon Chatelin
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引用次数: 0

Abstract

Purpose

From the myofibrils to the whole muscle scale, muscle micro-constituents exhibit passive and active mechanical properties, potentially coupled to electrical, chemical, and thermal properties. Experimental characterization of some of these properties is currently not available for all muscle constituents. Multiscale multiphysics models have recently gained interest as a numerical alternative to investigate the healthy and diseased physiological behavior of the skeletal muscle.

Methods

This paper refers to the multiscale mechanical models proposed in the literature to investigate the mechanical properties and behavior of skeletal muscles. More specifically, we focus on the scale transition methods, constitutive laws and experimental data implemented in these models.

Results

Using scale transition methods such as homogenization, coupled to appropriate constitutive behavior of the constituents, these models explore the mechanisms of ageing, myopathies, sportive injuries, and muscle contraction.

Conclusion

Emerging trends include the development of multiphysics simulations and the coupling of modeling with the acquisition of experimental data at different scales, with increasing focus to little known constituents such as the extracellular matrix and the protein titin.

Abstract Image

骨骼肌的多尺度力学建模:文献系统回顾
目的从肌原纤维到整个肌肉尺度,肌肉微观成分表现出被动和主动机械特性,并可能与电、化学和热特性相耦合。目前还无法对所有肌肉成分的某些特性进行实验表征。最近,多尺度多物理场模型作为研究骨骼肌健康和疾病生理行为的一种数值替代方法,受到了越来越多的关注。更具体地说,我们关注这些模型中实施的尺度转换方法、构成规律和实验数据。结果利用尺度转换方法(如均质化),结合成分的适当构成行为,这些模型探索了老化、肌病、运动损伤和肌肉收缩的机制。结论新出现的趋势包括多物理场模拟的发展以及建模与获取不同尺度实验数据的结合,并越来越关注鲜为人知的成分,如细胞外基质和蛋白质 titin。
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来源期刊
CiteScore
4.30
自引率
5.00%
发文量
81
审稿时长
3 months
期刊介绍: The purpose of Journal of Medical and Biological Engineering, JMBE, is committed to encouraging and providing the standard of biomedical engineering. The journal is devoted to publishing papers related to clinical engineering, biomedical signals, medical imaging, bio-informatics, tissue engineering, and so on. Other than the above articles, any contributions regarding hot issues and technological developments that help reach the purpose are also included.
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