Modern Dearomative Enlargement of Heteroaromatic Rings

Synthesis Pub Date : 2024-06-17 DOI:10.1055/a-2335-8799
Xavier Moreau, Clément Ghiazza
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Abstract

Breaking aromaticity by inserting additional atoms within the skeleton of heteroaromatic rings has gained significant attention over the years. As part of the emerging concept of ‘skeletal editing’, this short review retraces the recent progress made on dearomative enlargement reactions of both five- and six-membered heterocycles.

1 Introduction

2 Dearomative Enlargement of Five-Membered Rings

2.1 Pyrroles, Furans, Thiophenes and Their Fused Analogues

2.2 Pyrazoles, Isoxazoles, Isothiazoles and Their Fused Analogues

3 Dearomative Enlargement of Six-Membered Rings

4 Conclusion and Perspectives

Abstract Image

杂芳香族环的现代异构放大法
多年来,通过在杂芳香环的骨架中插入额外的原子来破坏芳香性的研究备受关注。作为新兴的 "骨架编辑 "概念的一部分,本短文回顾了五元和六元杂环的脱芳烃增大反应的最新进展。1 引言 2 五元环的脱芳放大反应 2.1 吡咯、呋喃、噻吩及其熔合类似物 2.2 吡唑、异噁唑、异噻唑及其熔合类似物 3 六元环的脱芳放大反应 4 结论与展望
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