Sex differences in chest electrical impedance tomography findings.

IF 2.3 4区医学 Q3 BIOPHYSICS

Physiological measurement Pub Date : 2024-07-12 DOI:10.1088/1361-6579/ad5ef7

I Frerichs, C Händel, T Becher, D Schädler

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引用次数: 0

Abstract

Objective.Electrical impedance tomography (EIT) has been used to determine regional lung ventilation distribution in humans for decades, however, the effect of biological sex on the findings has hardly ever been examined. The aim of our study was to determine if the spatial distribution of ventilation assessed by EIT during quiet breathing was influenced by biological sex.Approach.219 adults with no known acute or chronic lung disease were examined in sitting position with the EIT electrodes placed around the lower chest (6th intercostal space). EIT data were recorded at 33 images/s during quiet breathing for 60 s. Regional tidal impedance variation was calculated in all EIT image pixels and the spatial distribution of the values was determined using the established EIT measures of centre of ventilation in ventrodorsal (CoV_vd) and right-to-left direction (CoV_rl), the dorsal and right fraction of ventilation, and ventilation defect score.Main results.After exclusion of one subject due to insufficient electrode contact, 218 data sets were analysed (120 men, 98 women) (age: 53 ± 18 vs 50 ± 16 yr (p= 0.2607), body mass index: 26.4 ± 4.0 vs 26.4 ± 6.6 kg m^-2(p= 0.9158), mean ± SD). Highly significant differences in ventilation distribution were identified between men and women between the right and left chest sides (CoV_rl: 47.0 ± 2.9 vs 48.8 ± 3.3% of chest diameter (p< 0.0001), right fraction of ventilation: 0.573 ± 0.067 vs 0.539 ± 0.071 (p= 0.0004)) and less significant in the ventrodorsal direction (CoV_vd: 55.6 ± 4.2 vs 54.5 ± 3.6% of chest diameter (p= 0.0364), dorsal fraction of ventilation: 0.650 ± 0.121 vs 0.625 ± 0.104 (p= 0.1155)). Ventilation defect score higher than one was found in 42.5% of men but only in 16.6% of women.Significance.Biological sex needs to be considered when EIT findings acquired in upright subjects in a rather caudal examination plane are interpreted. Sex differences in chest anatomy and thoracoabdominal mechanics may explain the results.

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胸部电阻抗断层扫描结果的性别差异。

电阻抗断层扫描（EIT）用于确定人体肺通气的区域分布已有数十年的历史，但几乎从未研究过生理性别对研究结果的影响。我们的研究旨在确定安静呼吸时通过 EIT 评估的通气空间分布是否会受到生理性别的影响。219 名未患有已知急性或慢性肺部疾病的成年人在坐姿下接受了检查，EIT 电极被放置在胸部下方（第 6 肋间）。在所有 EIT 图像像素中计算区域潮气阻抗变化，并使用已建立的 EIT 测量值（通气中心在通气背侧（CoVvd）和右至左方向（CoVrl）、通气背侧和右侧部分以及通气缺陷评分）确定这些值的空间分布。主要结果：由于电极接触不足，排除了一名受试者，共分析了 218 组数据（120 名男性，98 名女性）（年龄：53±18 岁 vs 50±16 岁（P=0.2607），体重指数：26.4±4.0 vs 26.4±4.0）：26.4±4.0 vs 26.4±6.6 kg/m2 (p=0.9158), mean±SD）。男性和女性在左右胸腔两侧通气分布方面存在非常明显的差异（CoVrl：47.0±2.9 vs 48.8±3.3% 胸径（pvd：55.6±4.2 vs 54.5±3.6%胸径（P=0.0364），通气背侧部分：0.650±0.121 vs 0.625±0.104 (p=0.1155)）。42.5%的男性发现通气缺陷评分高于 1，而女性仅有 16.6%。胸部解剖和胸腹力学方面的性别差异可能解释了这一结果。

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来源期刊

Physiological measurement 生物-工程：生物医学

CiteScore

5.50

自引率

9.40%

发文量

124

审稿时长

3 months

期刊介绍： Physiological Measurement publishes papers about the quantitative assessment and visualization of physiological function in clinical research and practice, with an emphasis on the development of new methods of measurement and their validation. Papers are published on topics including: applied physiology in illness and health electrical bioimpedance, optical and acoustic measurement techniques advanced methods of time series and other data analysis biomedical and clinical engineering in-patient and ambulatory monitoring point-of-care technologies novel clinical measurements of cardiovascular, neurological, and musculoskeletal systems. measurements in molecular, cellular and organ physiology and electrophysiology physiological modeling and simulation novel biomedical sensors, instruments, devices and systems measurement standards and guidelines.