Thymic stromal lymphopoietin and digital microvascular damage in systemic sclerosis patients: A pilot study

IF 2.9 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Microvascular research Pub Date : 2024-07-01 DOI:10.1016/j.mvr.2024.104714

Chiara Pellicano , Giuseppina Cusano , Umberto Basile , Edoardo Rosato

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引用次数: 0

Abstract

Background

Systemic sclerosis (SSc) is a complex autoimmune connective-tissue disease, characterised by vasculopathy and fibrosis of the skin and internal organs. Activation of microvascular endothelial cells (ECs) causes the intimal hyperplasia that characterises the vascular remodelling in SSc. The most frequent complication of SSc is the development of digital ulcers (DUs). Thymic stromal lymphopoietin (TSLP) may trigger fibrosis and sustain vascular damage. Aim of this study was to evaluate the correlation between serum level of TSLP and DUs.

Methods

75 consecutive SSc patients were enrolled and serum TSLP levels were measured. The presence of history of DUs (HDU) was evaluated. Recurrent new DUs were defined as the presence of at least 3 episodes of DUs in a 12-months follow up period. The risk of developing new DUs was calculated by applying the capillaroscopic skin ulcer risk index (CSURI).

Results

The median value of TSLP was higher in patients with HDU than patients without HDU [181.67 pg/ml (IQR 144.67; 265.66) vs 154.67 pg/ml (IQR 110.67; 171.33), p < 0.01]. The median value of TSLP was higher in patients with an increased CSURI index than patients without an increased CSURI [188 pg/ml (IQR 171.33; 246.33) vs 159.33 pg/ml (IQR 128.67; 218), p < 0.01]. Kaplan-Meier curves demonstrated that free survival from new DUs was significantly (p < 0.01) lower in SSc patients with increased TSLP serum levels.

Conclusion

TSLP might have a key role in digital microvascular damage of SSc patients.

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胸腺基质淋巴细胞生成素与系统性硬化症患者的数字微血管损伤：试点研究

背景：系统性硬化症（SSc）是一种复杂的自身免疫性结缔组织疾病，以血管病变和皮肤及内脏器官纤维化为特征。微血管内皮细胞（ECs）的活化导致血管内膜增生，这是 SSc 血管重塑的特征。SSc 最常见的并发症是出现数字溃疡（DUs）。胸腺基质淋巴细胞生成素（TSLP）可能会引发纤维化和血管损伤。本研究旨在评估血清 TSLP 水平与 DUs 之间的相关性。评估是否存在DUs病史（HDU）。复发性新DU的定义是在12个月的随访期内至少出现3次DU。采用毛细血管镜皮肤溃疡风险指数（CSURI）计算新发皮肤溃疡的风险：结果：HDU 患者的 TSLP 中位值高于非 HDU 患者[181.67 pg/ml (IQR 144.67; 265.66) vs 154.67 pg/ml (IQR 110.67; 171.33), p 结论：TSLP 在 HDU 中可能起着关键作用：TSLP可能在SSc患者的数字微血管损伤中起着关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microvascular research 医学-外周血管病

CiteScore

6.00

自引率

3.20%

发文量

158

审稿时长

43 days

期刊介绍： Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured. Research Areas include: • Angiogenesis • Biochemistry • Bioengineering • Biomathematics • Biophysics • Cancer • Circulatory homeostasis • Comparative physiology • Drug delivery • Neuropharmacology • Microvascular pathology • Rheology • Tissue Engineering.