Roles of long non‑coding RNAs in esophageal cell squamous carcinoma (Review).

IF 5.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
International journal of molecular medicine Pub Date : 2024-08-01 Epub Date: 2024-07-04 DOI:10.3892/ijmm.2024.5396
Qihang Yan, Wingshing Wong, Li Gong, Jie Yang, Dachuan Liang, Kok-Yong Chin, Shuqin Dai, Junye Wang
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引用次数: 0

Abstract

Esophageal squamous cell carcinoma (ESCC) is a prevalent and deadly malignancy of the digestive tract. Recent research has identified long non‑coding RNAs (lncRNAs) as crucial regulators in the pathogenesis of ESCC. These lncRNAs, typically exceeding 200 nucleotides, modulate gene expression through various mechanisms, including the competing endogenous RNA (ceRNA) pathway and RNA‑protein interactions. The current study reviews the multifaceted roles of lncRNAs in ESCC, highlighting their involvement in processes such as proliferation, migration, invasion, epithelial‑mesenchymal transition, cell cycle progression, resistance to radiotherapy and chemotherapy, glycolysis, apoptosis, angiogenesis, autophagy, tumor growth, metastasis and the maintenance of cancer stem cells. Specific lncRNAs like HLA complex P5, LINC00963 and non‑coding repressor of NFAT have been shown to enhance resistance to radio‑ and chemotherapy by modulating pathways such as AKT signaling and microRNA interaction, which promote cell survival and proliferation under therapeutic stress. Furthermore, lncRNAs like family with sequence similarity 83, member A antisense RNA 1, zinc finger NFX1‑type containing 1 antisense RNA 1 and taurine upregulated gene 1 are implicated in enhancing invasive and proliferative capabilities of ESCC cells through the ceRNA mechanism, while interactions with RNA‑binding proteins further influence cancer cell behavior. The comprehensive analysis underscores the potential of lncRNAs as biomarkers for prognosis and therapeutic targets in ESCC, suggesting avenues for future research focused on elucidating the detailed molecular mechanisms and clinical applications of lncRNAs in ESCC management.

长非编码 RNA 在食管鳞状细胞癌中的作用(综述)。
食管鳞状细胞癌(ESCC)是消化道常见的致命恶性肿瘤。最近的研究发现,长非编码 RNA(lncRNA)是食管鳞癌发病机制中的关键调控因子。这些lncRNA通常超过200个核苷酸,通过各种机制调节基因表达,包括竞争性内源性RNA(ceRNA)途径和RNA与蛋白质的相互作用。目前的研究回顾了lncRNA在ESCC中的多方面作用,强调了它们在增殖、迁移、侵袭、上皮-间质转化、细胞周期进展、放疗和化疗抗性、糖酵解、凋亡、血管生成、自噬、肿瘤生长、转移和癌症干细胞维持等过程中的参与。具体的 lncRNAs,如 HLA 复合物 P5、LINC00963 和 NFAT 非编码抑制因子,已被证明可通过调节 AKT 信号转导和 microRNA 相互作用等通路,增强对放疗和化疗的抵抗力,从而促进细胞在治疗压力下的存活和增殖。此外,序列相似性83家族成员A反义RNA 1、锌指NFX1型含1反义RNA 1和牛磺酸上调基因1等lncRNA也被认为通过ceRNA机制增强了ESCC细胞的侵袭和增殖能力,而与RNA结合蛋白的相互作用则进一步影响了癌细胞的行为。综合分析强调了lncRNA作为ESCC预后生物标志物和治疗靶点的潜力,为今后重点阐明lncRNA在ESCC治疗中的详细分子机制和临床应用提出了研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International journal of molecular medicine
International journal of molecular medicine 医学-医学:研究与实验
CiteScore
12.30
自引率
0.00%
发文量
124
审稿时长
3 months
期刊介绍: The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.
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