Impact of SGLT2 Inhibitors on Renal Function in Type 2 Diabetic Patients with Coronary Artery Disease Undergoing Percutaneous Intervention: A Systematic Review and Meta-Analysis.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Roopa Satyanarayan Basutkar, Rasheal Maria Cutinha, Varshini Sathish, Aboobacker Shahil, Najad Saneen Ck
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Abstract

Background and objectives: Contrast agents directly cause kidney toxicity in patients undergoing Percutaneous Intervention for cardiovascular disease with Type 2 diabetes. This meta-analysis aims to evaluate the effects of SGLT2-i on renal function in individuals undergoing Percutaneous Intervention.

Methods: The databases used for the search included PubMed, Scopus, Cochrane Central Registry of Controlled Trials, and Google Scholar. We considered Randomized controlled trials and observational studies published from January 2013 to August 2023. The eligibility to include the studies was assessed independently. The Cochrane modified data extraction form, and Joanna Briggs Institute was used. The Cochrane risk of bias tool and Newcastle-Ottawa quality assessment scale were used to assess the quality of the studies. The certainty of the evidence was assessed using GradePro software.

Results: The pooled estimate showed a substantial reduction in serum creatinine levels at 48- and 72-hours post-PCI who received SGLT2i (MD -9.57; 95% CI -18.36, -0.78; p-value 0.03) and (MD -14.40; 95% CI -28.57, -0.22; p-value 0.05). There was a decrease in the incidence of the CI-AKI among SGT2i users (RR: 0.46; 95% CI: 0.32, 0.67; p value< 0.0001). There was no significant difference in the number of patients requiring hemodialysis, but a smaller number of patients required hemodialysis among the SGLT2i users (RR: 0.88; 95% CI: 0.19, 4.07; p-value = 0.87).

Conclusions: The use of SGLT2i confers substantial beneficial effects on kidney function and reduction of incidence of Contrast-induced acute kidney injury among patients undergoing PCI procedures for cardiovascular disease with diabetes.

SGLT2抑制剂对接受经皮介入治疗的2型糖尿病冠心病患者肾功能的影响:系统回顾与元分析》。
背景和目的:造影剂会直接导致接受经皮介入治疗的 2 型糖尿病心血管疾病患者的肾脏毒性。本荟萃分析旨在评估 SGLT2-i 对经皮介入治疗患者肾功能的影响:用于检索的数据库包括 PubMed、Scopus、Cochrane Central Registry of Controlled Trials 和 Google Scholar。我们考虑了 2013 年 1 月至 2023 年 8 月期间发表的随机对照试验和观察性研究。我们对纳入研究的资格进行了独立评估。我们使用了 Cochrane 修改过的数据提取表和乔安娜-布里格斯研究所(Joanna Briggs Institute)的数据提取表。评估研究质量时使用了 Cochrane 偏倚风险工具和纽卡斯尔-渥太华质量评估量表。使用 GradePro 软件评估证据的确定性:汇总估算结果显示,PCI 术后 48 小时和 72 小时接受 SGLT2i 治疗的患者血清肌酐水平大幅下降(MD -9.57;95% CI -18.36,-0.78;P 值 0.03)和(MD -14.40;95% CI -28.57,-0.22;P 值 0.05)。SGT2i使用者的CI-AKI发生率有所下降(RR:0.46;95% CI:0.32,0.67;P值< 0.0001)。需要血液透析的患者人数没有明显差异,但SGLT2i使用者中需要血液透析的患者人数较少(RR:0.88;95% CI:0.19,4.07;P值=0.87):结论:使用SGLT2i对心血管疾病合并糖尿病的PCI患者的肾功能有很大的益处,并能降低Contrast诱导的急性肾损伤的发生率。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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